论文部分内容阅读
目的评估七价肺炎球菌结合疫苗(PCV7)的保护效果。方法采用前瞻性队列研究设计,比较2岁以下儿童中PCV7全程接种组和非接种组肺炎、支气管炎发病风险的差异,以评估PCV7的保护效果。结果 PCV7接种组肺炎、支气管累积发病率分别为2.08%、4.58%,对照组分别为3.33%、6.88%,两组肺炎、支气管累积发病率差异均有统计学意义(均<0.05);2周岁以下婴幼儿肺炎、支气管炎疾病发生率分别减少了54.59%(95%CI:5.40%~79.30%)和51.60%(95%CI:13.30%~73.40%)。结论对于2周岁以下儿童全程接种PCV7可以降低肺炎和支气管炎的发病风险。
Objective To evaluate the protective effect of seven-valent pneumococcal conjugate vaccine (PCV7). Methods A prospective cohort study was designed to compare the differences in the risk of pneumonia and bronchitis between PCV7 vaccinated and non-vaccinated children under 2 years of age in order to assess the protective effect of PCV7. Results The incidence rates of pneumonia and bronchus in PCV7 vaccinated group were 2.08% and 4.58% respectively, while those in control group were 3.33% and 6.88% respectively. There were significant differences in the cumulative incidence of pneumonia and bronchus between the two groups (all P <0.05) The following infantile pneumonia, bronchitis disease rates decreased by 54.59% (95% CI: 5.40% ~ 79.30%) and 51.60% (95% CI: 13.30% ~ 73.40%). Conclusion PCV7 can reduce the risk of pneumonia and bronchitis in children under 2 years of age.