遗传素质是系统性红班狼疮（ SLE）发病的主要因素之一，众多研究结果揭示 HLA D区与 SLE发病密切相关，并认为以其中的 DQ位点关联更强，我们采用聚合酶链反应（ PCR）结合顺序特异性的寡核苷酸探针（ SSO）杂交方法从分子生物学的角度探讨了 HLA DQ位点等位基因多态性与 Hereditary quality is one of the main factors in systemic lupus erythematosus (SLE). Many studies have revealed that HLA-D is closely related to the pathogenesis of SLE and considered to be more associated with DQ. We used polymerase chain reaction (PCR) combined with sequence-specific oligonucleotide probe (SSO) hybridization method from the molecular biological point of view HLA DQ locus allele polymorphism and