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多次多发表浅乳头状膀胱癌和并发的扁平原位癌(CIS)有肿瘤复发或持续的高度危险(95%).1976年 Morales 等报道 BCG 膀胱腔内灌注可明显减少复发肿瘤的数量,以后又报道在7例 BCG 治疗患者中,5例短期(0.5～1年)根除了扁平原位癌。病人:86例患者,平均年龄为60岁(40～77岁).患者均为具有高度复发危险的肿瘤(≥4个肿瘤和/或以前连续膀胱镜检查2次均有>3个复发肿瘤),组织学证据(乳头状癌及扁平原位癌,Ⅱ～Ⅳ级,Tis、Ta、T_1期),但不需膀胱切除者.
Multiple times of superficial papillary bladder cancer and concurrent CIS have a high risk of tumor recurrence or persistent (95%). In 1976 Morales et al reported that intravesical instillation of BCG can significantly reduce the number of recurrent tumors. It was later reported that of the 7 BCG-treated patients, 5 had short-term (0.5 to 1 year) eradication of flat carcinoma in situ. Patients: 86 patients with an average age of 60 years (40-77 years old). Patients were all tumors with a high risk of recurrence (>4 tumors and/or> 3 consecutive recurrent tumors in 2 previous consecutive cystoscopy) Histological evidence (papillary carcinoma and flat carcinoma in situ, grades II-IV, Tis, Ta, T1), but no cystectomy.