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目的：进行老年人口服１０ｍｇ爱普列特的单次给药药代动力学试验。方法：用ＨＰＬＣ法测定给药后的血药浓度。结果：测定的主要药代动力学参数为：Ｃｍａｘ＝０．１８±０．０７ｍｇ·Ｌ－１；Ｔ１／２Ｂ＝５．０９±２．７３ｈ；ＡＵＣ＝１．８５±０．６９ｍｇ·ｈ·Ｌ－１；Ｖ（ｃ）／Ｆ ３８．１７±１１．１５Ｌ；Ｔｐｅａｋ＝２．９９±０．４９ｈ。结论：爱普列特在老年人体内的药代动力学特性在同剂量下与青年人的一致。
OBJECTIVE: To carry out a single-dose pharmacokinetic test of 10 mg of epristeride orally administered to the elderly. Methods: HPLC method for the determination of blood concentration after administration. Results: The main pharmacokinetic parameters measured were: Cmax = 0.18 ± 0.07 mg · L -1; T1 / 2B = 5.09 ± 2.73 h; AUC = 1.85 ± 0.69 mg · h · L-1; V (c) / F 38.17 ± 11.15 L; Tpeak = 2.99 ± 0.49 h. Conclusions: The pharmacokinetics of epristeride in the elderly are consistent with those of young adults at the same dose.