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目的探讨血脑钠素N端前体肽(Nt BNP)在急性脑梗死患者中的临床检测意义。方法采用放射免疫分析法测定74例脑梗死急性期患者(作为梗死组)血浆NTBNP含量,并以40例健康自愿体检者作为对照组。结果梗死组急性期患者血浆Nt BNP含量明显高于对照组(P<0.05);中梗死灶组、大梗死灶组Nt BNP含量均明显高于小梗死灶组,大梗死灶组Nt BNP含量高于中梗死灶组(P<0.05)。不同梗死部位患者Nt BNP浓度无明显差别(P>0.05)。结论急性脑梗死患者血Nt BNP升高,说明其与脑梗死的发生密切相关,可能在脑梗死的发病过程中起重要作用,可作为有效的诊断指标之一。
Objective To investigate the clinical significance of N-terminal pro-brain peptide (Nt-BNP) in patients with acute cerebral infarction. Methods The plasma levels of NTBNP in 74 patients with acute cerebral infarction (as infarction group) were measured by radioimmunoassay. Forty healthy volunteers were used as control group. Results The plasma level of Nt BNP in the infarction group was significantly higher than that in the control group (P <0.05). The levels of Nt BNP in the middle infarction group and the large infarction group were significantly higher than those in the small infarction group and in the large infarction group In the infarction group (P <0.05). Nt BNP concentrations in patients with different infarct sites showed no significant difference (P> 0.05). Conclusions The elevation of Nt BNP in blood of patients with acute cerebral infarction indicates that it is closely related to the occurrence of cerebral infarction and may play an important role in the pathogenesis of cerebral infarction and may be used as an effective diagnostic indicator.