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目的通过对南京地区34家医院2010-2012年抗真菌药物使用情况的分析,评价近年来抗真菌药物治疗情况。方法采用金额和用药频度(DDDs)分析及排序法进行药物利用分析。结果①抗真菌药物占抗菌药物的总金额呈逐年增加趋势,其中2011年增长率最高为10.8%。②抗真菌药物金额构成比最大的是深部真菌感染用药,尤其是三唑类药物,年均增长率为10.5%。③抗真菌药物通用名金额排序中三唑类药物排在前列,伏立康唑排名从2010年的第3位上升到2012年的第1位。④抗真菌药物DDDs排序中,深部真菌感染用药氟康唑和伊曲康唑排在前列,浅表部真菌感染用药特比萘芬排名也居前。结论2010-2012年南京地区34家医院使用抗真菌药物结构相对合理,用药金额增长较为显著,深部真菌感染用药趋于选用三唑类,浅表真菌感染趋于使用特比萘芬。
Objective To evaluate the antifungal therapy in 34 hospitals in Nanjing in 2010-2012. Methods The drug use analysis was conducted by the methods of amount and frequency of medication (DDDs) and sequencing. Results ① The total amount of anti-fungals and antimicrobials increased year by year with the highest growth rate of 10.8% in 2011. ② The composition of the proportion of anti-fungal drugs is the largest deep fungal infection medication, especially triazole drugs, with an average annual growth rate of 10.5%. ③ anti-fungal generic name the amount of the ranking of triazole drugs in the forefront, voriconazole from third in 2010 ranking rose to 2012 first place. ④ In the order of antifungal DDDs, fluconazole and itraconazole in the deep fungal infections were ranked in the forefront, and topical fungal infections drug terbinafine ranked first. CONCLUSIONS: The antifungal agents used in 34 hospitals in Nanjing during 2010-2012 are relatively reasonable and the amount of medication increased significantly. The treatment of deep fungal infections tended to use triazoles, and the superficial fungous infections tended to use terbinafine.