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观察了川芎嗪对家兔心肌缺血再灌注损伤时血清中和心肌组织中氧自由基和脂质过氧化物的影响。结果显示川芎嗪保护组和非保护组比较，血清中ＭＤＡ（丙二醛）明显降低（Ｐ＜０．０５），ＧＳＨ－ＰＸ／ＬＰＯ（谷胱甘肽过氧化物酶／脂质过氧化物）升高非常显著（Ｐ＜０．０１）；缺血再灌注损伤心肌组织中ＭＤＡ明显降低，且伴随ＳＯＤ（超氧化物歧化酶）活力和ＧＳＨ－ＰＸ／ＬＰＯ明显升高（均Ｐ＜０．０５）。表明川芎嗪能通过提高对氧自由基的清除和抗脂质过氧化反应而保护缺血再灌注损伤的心肌。
The effects of tetramethylpyrazine on oxygen free radicals and lipid peroxides in serum and myocardial tissue during myocardial ischemia reperfusion injury in rabbits were observed. The results showed that compared with the unprotected group, the content of MDA (malondialdehyde) in serum was significantly decreased (P<0.05). GSH-PX/LPO (glutathione peroxidase/lipid peroxide ) The increase was very significant (P<0.01); MDA in myocardial tissue after ischemia-reperfusion injury was significantly decreased, with the increase of SOD (superoxide dismutase) activity and GSH-PX/LPO (both P<0). .05). It was shown that ligustrazine protects myocardium from ischemia-reperfusion injury by increasing the clearance of oxygen free radicals and anti-lipid peroxidation.