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目的观察帕瑞昔布对非计划哺乳产妇剖宫产术后的镇痛效果及对吗啡的节俭作用。方法选择腰硬联合麻醉下行剖宫产的非计划哺乳产妇40例,ASA均为Ⅰ～Ⅱ级,随机分为2组:P组为帕瑞昔布组(n=20),C组为对照组(n=20)。分别给药,并对每组的一般资料及药物疗效进行观察比较。结果①两组术后滴注缩宫素期间,P组VAS评分低于C组,差异有显著性(P<0.05);其他时间点差异无显著性。②术后恶心呕吐的发生率P组明显低于C组(P<0.05)。③两组产妇术后皮肤瘙痒的发生率差异无显著性。④P组的首次肛门排气时间明显短于C组(P<0.05)。⑤两组产妇术后24h出血量差异无统计学意义。结论帕瑞昔布能减轻子宫收缩性疼痛,对吗啡有节俭作用,并减少吗啡相关的不良反应。
Objective To observe the analgesic effect of parecoxib on cesarean section after unplanned lactation and the thrift effect on morphine. Methods Forty unplanned breastfeeding mothers undergoing combined spinal and epidural anesthesia for cesarean delivery were randomly divided into two groups: Parecoxib group (n = 20), C group as control group Group (n = 20). Were administered, and each group of general information and drug efficacy were observed and compared. Results ① The VAS score of P group was lower than that of C group in both groups (P <0.05). There was no significant difference at other time points. ② The incidence of postoperative nausea and vomiting was significantly lower in group P than in group C (P <0.05). ③ There was no significant difference in the incidence of skin pruritus between the two groups. ④ The time of first anal exhaust in group P was significantly shorter than that in group C (P <0.05). ⑤ 24h postoperative 24h bleeding no significant difference. Conclusions Parecoxib can reduce uterine contractile pain, have a thrifty effect on morphine, and reduce morphine-related adverse reactions.