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本研究采用改进的Fisher和Kamada大鼠原位肾移植模型，选用SD大鼠肾移植结Wistar大鼠为同种异体移植，Wistar－to－Wistar同品系移植为正常对照，根据使用药物不同分五个实验组，观察移植后受体鼠存活、肾功能及定量测定移植肾内MHCClassⅡ在移植肾内的表达。结果表明，草药S能延长受体鼠存活时间，并抑制MHCClassⅡ在移植肾内的表达（VS．未治疗组P＜0．01），S药加小剂量环孢素A（CsA）治疗组与同系组相比差异无显著性（P＞0．05）。这些结果提示，移植肾内MHCClassⅡ表达的多少与其排斥的强弱有相关性，草药S的抗排斥机理之一可能与抑制移植紧排斥反应中MHCClassⅡ分子表达有关。
In this study, an improved model of orthotopic kidney transplantation in Fisher and Kamada rats was adopted. Wistar rats were transplanted with renal transplantation of SD rats as allografts. Wistar-to-Wistar rats were transplanted as normal controls. A group of experimental mice were used to observe the survival and renal function of the recipient mice after transplantation. The expression of MHCC class II in the transplanted kidneys was quantitatively determined. The results showed that herbal medicine S could prolong the survival time of recipient mice and inhibit the expression of MHCClass Ⅱ in renal transplant recipients (VS. Untreated group, P <0.01). S and CsA groups Compared with the same group no significant difference (P> 0.05). These results suggest that there is a correlation between the expression of MHCClass Ⅱ in renal grafts and the intensity of its rejection. One of the mechanisms of anti-rejection of herbal S may be related to the inhibition of expression of MHCClass Ⅱ in graft rejection.