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目的探讨联合检测脂蛋白a[LP(a)]、胱抑素C(Cys-C)和尿酸(UA)在高血压并发脑梗死诊断中的价值。方法分别采用胶乳增强免疫透射比浊法和URO-PAP法检测85例高血压并发脑梗死患者、71例单纯高血压患者及80例健康者血清中LP(a)、Cys-C和UA的含量。结果 LP(a)、Cys-C和UA在高血压并发脑梗死患者血清中的浓度均高于单纯高血压组和正常对照组,差异有统计学意义(P<0.05);且高血压并发脑梗死组LP(a)、Cys-C和UA阳性率高于单纯高血压组,LP(a)、Cys-C和UA 3项指标联合检测阳性率明显高于各指标单项检测,差异有统计学意义(P<0.05);且高血压并发脑梗死组血清3项指标表达水平两两之间均呈正相关(P<0.05)。结论 LP(a)、Cys-C和UA联合检测可显著提高高血压并发脑梗死诊断的阳性率,对于脑梗死的早期预防和诊断具有十分重要的临床指导意义。
Objective To investigate the value of combined detection of lipoprotein a [LP (a)], cystatin C (Cys-C) and uric acid (UA) in the diagnosis of hypertension complicated by cerebral infarction. Methods The serum levels of LP (a), Cys-C and UA in 85 hypertensive patients with cerebral infarction, 71 hypertensive patients and 80 healthy controls were detected by latex enhanced immunoturbidimetry and URO-PAP respectively. . Results The serum concentrations of LP (a), Cys-C and UA in patients with hypertension complicated by cerebral infarction were significantly higher than those in patients with hypertension and normal controls (P <0.05). Hypertension complicated with brain The positive rates of LP (a), Cys-C and UA in the infarction group were higher than those in the hypertension group. The positive rates of LP (a), Cys-C and UA in the infarction group were significantly higher than those in the individual indexes (P <0.05). There was a positive correlation between the serum levels of three indicators of hypertension and cerebral infarction (P <0.05). Conclusions The combined detection of LP (a), Cys-C and UA can significantly increase the positive rate of diagnosis of hypertension complicated by cerebral infarction, which is of great clinical significance for early prevention and diagnosis of cerebral infarction.