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目的比较新生儿脐血溶血和静脉血3项检测结果,分析脐带血在诊断新生儿ABO溶血病(ABO-HDN)中的应用价值。方法收集2015年1-6月在青岛大学附属医院黄岛分院产科分娩的245例足月健康新生儿的脐带血(出生后立即抽取)和静脉血(出生后3 d内抽取)采用直接抗人血球蛋白试验、游离抗体试验和抗体释放试验进行检测分析。结果新生儿脐带血ABO-HDN的确诊率显著高于静脉血(P<0.01);男婴和女婴脐带血ABO-HDN的确诊率比较,差异无统计学意义(P>0.05);O/A型新生儿脐带血ABO-HDN的确诊率显著高于O/B型新生儿(P<0.01)。结论 ABO新生儿出生后立即抽取脐血进行溶血3项检测有助于ABO-HDN的早期诊断,对于提高ABO-HDN检出率具有重要意义。
Objective To compare the results of cord blood hemolytic and venous blood tests in neonates with cord blood in the diagnosis of neonatal ABO hemolytic disease (ABO-HDN). Methods The umbilical cord blood samples (taken immediately after birth) and venous blood (drawn within 3 days after birth) of 245 full-term healthy newborns delivered from January 2015 to March 2015 in Huangdao Branch Hospital of Qingdao University were collected. Hemoglobin test, free antibody test and antibody release test for analysis. Results The positive rate of ABO-HDN in cord blood of neonates was significantly higher than that of venous blood (P <0.01). There was no significant difference in the diagnostic rate of ABO-HDN between male and female umbilical cord blood (P> 0.05) The diagnosis rate of ABO-HDN in type A neonates was significantly higher than that in type O / B neonates (P <0.01). Conclusion The detection of ABO-HDN in ABO-HDN is helpful for the detection of ABO-HDN in ABO-HDN.