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目的观察参附注射液对新生儿重度窒息复苏后患者的多脏器功能的临床保护作用。方法采用随机数字表法将患儿分为观察组和对照组各40例,观察组加用参附注射液,比较两组患者血清肌酸激酶同工酶(CK-MB)、血清丙氨酸氨基转移酶(ALT)、血清门冬氨酸氨基转移酶(AST)、肌酐(Cr)、血清神经元特异性烯醇化酶(NSE)水平以及氧合指数(PO2/Fi O2),新生儿神经行为评分、两组患者生存率以及生存时间。结果观察组的CK-MB、ALT、AST、s Cr以及NSE显著降低,PO2/Fi O2显著升高(P<0.05);观察组新生儿神经行为评分显著高于对照组(P<0.05);入组后第14天观察组存活率77.5%,对照组存活55.0%,两组生存率以及总体生存率比较差异均有统计学意义(P<0.05)。结论参附注射液可以减轻重度窒息新生儿重要脏器缺氧缺血-再灌注损伤,保护多脏器功能,改善神经行为能力,提高患儿生存率。
Objective To observe the clinical protective effect of Shenfu injection on multiple organ function in neonates with severe asphyxia and resuscitation. Methods The children were divided into observation group (40 cases) and control group (40 cases) by random number table. The observation group was treated with Shenfu injection. The serum CK-MB, serum alanine ALT, AST, Cr, NSE and oxygenation index (PO2 / Fi O2), neonatal nerve Behavioral score, survival rate and survival time in two groups. Results The levels of CK-MB, ALT, AST, s Cr and NSE in observation group decreased significantly and PO2 / Fi O2 increased significantly (P <0.05). Neonatal behavioral score in observation group was significantly higher than that in control group (P <0.05). On the 14th day after operation, the survival rate of the observation group was 77.5%, while that of the control group was 55.0%. There was significant difference between the two groups in survival rate and overall survival rate (P <0.05). Conclusion Shenfu injection can reduce the hypoxic-ischemic-reperfusion injury in important organs of neonates with severe asphyxia, protect the function of multiple organs, improve the neurobehavioral ability and improve the survival rate of children.