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:目的 :评价奥沙利铂联合 5 -氟尿嘧啶 (5 -Fu)—四氢叶酸 (CF)治疗大肠癌的疗效及毒副反应。方法 :收治大肠癌晚期患者 38例 ,按随机方法 ,分别入试验组 2 0例 (奥沙利铂 +5Fu +CF)和对照组 18例 (5 -Fu +CF)。结果 :试验组有效率为 30 0 % ,对照组 5 6 % ,试验组疗效明显优于对照组 (P <0 .0 1) ,且奥沙利铂对大肠癌常见转移部位如肝脏、腹腔淋巴结、盆腔及肺脏均可见临床疗效 ,毒副反应主要为神经感觉异常 ,其中重度异常为 10 %。结论 :奥沙利铂联合 5 -Fu、CF治疗大肠癌疗效肯定 ,耐受性良好 ,值得临床进一步研究和扩大应用
OBJECTIVE: To evaluate the efficacy and toxicity of oxaliplatin combined with 5-fluorouracil (5-Fu)-tetrahydrofolate (CF) in the treatment of colorectal cancer. Methods: Thirty-eight patients with advanced colorectal cancer were randomized into 20 patients (Oxaliplatin+5Fu+CF) and 18 patients (5-Fu+CF). Results: The effective rate was 30.0% in the experimental group and 56.6% in the control group. The efficacy of the experimental group was significantly better than that of the control group (P < 0.01), and the common metastatic sites of oxaliplatin on colorectal cancer were liver and abdominal lymph nodes. The clinical efficacy was seen in pelvic cavity and lungs, and the toxic and side effects were mainly neurosensory abnormalities, with a severe abnormality of 10%. Conclusion: Oxaliplatin combined with 5-Fu, CF is effective in the treatment of colorectal cancer and has good tolerability. It is worthy of further clinical research and application.