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原发性肝癌(hepatocellular carcinoma,HCC)是当今世界病死率较高的恶性肿瘤之一,从分子生物学角度看,其发生涉及原癌基因激活和抑癌基因失活等多基因改变的过程。随着对细胞周期调控系统研究的不断深入,人们愈来愈认识到细胞周期调控紊乱与恶性肿瘤的关系,认为细胞周期调控异常是肿瘤发生、发展的重要机制,并提出了“肿瘤可能是一
Hepatocellular carcinoma (HCC) is one of the most malignant tumors in the world today. From molecular biology perspective, HCC is involved in the process of multi-gene alteration such as activation of oncogenes and inactivation of tumor suppressor genes. With the deepening of research on cell cycle regulation system, people are more aware of the relationship between cell cycle regulation disorder and malignant tumor. It is believed that abnormal cell cycle regulation is an important mechanism of tumorigenesis and development. It is proposed that ”the tumor may be one