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目的:观察祛瘀化痰方对动脉粥样硬化大鼠血液流变学的作用。方法:采用维生素D3结合高脂饲料法建立大鼠动脉粥样硬化模型,经药物治疗8周后,取腹主动脉血测定血液流变学相关指标。结果:与模型对照组比较,祛瘀化痰方两个剂量组能显著降低血细胞比容(P<0.001),也能降低两个剂量组的血浆黏度和全血黏度的水平(P<0.05~P<0.001),对高剂量组血浆纤维蛋白原含量也能明显降低(P<0.05),对血小板聚集有明显降低趋势,但无统计学意义(P>0.05)。结论:祛瘀化痰方可改善动脉粥样硬化大鼠血液流变学异常,阻止动脉粥样硬化病变发展。
Objective: To observe the effect of Quyu Huatan Fang on the hemorheology of atherosclerosis rats. Methods: The model of atherosclerosis was established by using vitamin D3 combined with high-fat diet. After 8 weeks of drug treatment, the indexes of hemorrheology were measured by abdominal aorta blood. Results: Compared with the model control group, the two groups of Quxu Huatan Decoction could significantly reduce the hematocrit (P <0.001), and also reduce the plasma viscosity and whole blood viscosity of the two dose groups (P <0.05 ~ P <0.001). The levels of plasma fibrinogen in high dose group were also significantly decreased (P <0.05), while the platelet aggregation was significantly decreased. However, there was no statistical significance (P> 0.05). Conclusion: Expelling Stasis and Phlegm can ameliorate the abnormal hemorheology in atherosclerotic rats and prevent the development of atherosclerotic lesions.