目的通过2477例不育男性的染色体检查分析,探讨遗传性因素在男性不育症中的重要性。方法采取2477例不育男性的外周血进行染色体核型分析。结果检出染色体异常465例,阳性检出率为18．7%,其中明显异常348例(14．0%),多态等微细变异117例(4．7%)。结论染色体异常是男性不育的重要病因,染色体检查不但有助于明确诊断而且可避免盲目治疗。 Objective To investigate the importance of hereditary factors in male infertility by analyzing the chromosomes of 2477 infertile men. Methods Chromosomal karyotype analysis was performed on peripheral blood of 2477 infertile men. Results 465 chromosomal abnormalities were detected, the positive rate was 18.7%, of which 348 were significantly abnormal (14.0%) and 117 were polymorphic (4.7%). Conclusions Chromosomal abnormalities are an important cause of male infertility. Chromosome examination not only helps to confirm the diagnosis but also avoids blind treatment.