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目的探讨长期服用血脂康对脑梗死患者的颈动脉粥样硬化斑块和血清C反应蛋白(CRP)的影响。方法 61例有动脉粥样斑块的脑梗死患者随机分为血脂康组和对照组,利用彩色多普勒超声仪测量患者颈动脉中-内膜厚度(IMT)和粥样斑块大小,并检测血清CRP水平和总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)及高密度脂蛋白(HDL-C)水平。观察治疗24周后上述指标的变化。结果治疗后血脂康组CRP水平、TC、TG、LDL-C明显下降,HDL-C明显升高;IMT和粥样斑块变小,且差异具有统计学意义。结论血脂康具有抗炎,抗动脉粥样硬化,逆转粥样硬化斑块的作用,进而对脑梗死的发生起预防作用。
Objective To investigate the effect of long-term administration of Xuezhikang on carotid atherosclerosis plaque and serum C-reactive protein (CRP) in patients with cerebral infarction. Methods Sixty-one patients with atherosclerotic cerebral infarction were randomly divided into Xuezhikang group and control group. The carotid intima-media thickness (IMT) and plaque size were measured by color Doppler sonography. Serum CRP levels and total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) levels were measured. Observed after 24 weeks of treatment of these indicators changes. Results After treatment Xuezhikang CRP levels, TC, TG, LDL-C decreased significantly, HDL-C was significantly increased; IMT and atheroma plaque smaller, and the difference was statistically significant. Conclusion Xuezhikang has anti-inflammatory, anti-atherosclerosis, reverse the role of atherosclerotic plaque, and thus play a preventive role in the occurrence of cerebral infarction.