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目的探讨中药注射剂与其他药剂配伍禁忌的原因及其解决对策。方法将2013年1月至2014年10月食品药品监督管理部门官方网站发布的关于中药注射剂发生不良反应事件中的40例患者作为研究对象。根据中药注射剂与之配伍药品类型对所有患者使用中药注射剂的情况进行统计、分类和详细分析,观察其配伍禁忌发生的相关原因,并提出相应的解决对策。结果 40例患者中,因清开灵注射液发生头晕、恶心12例,占30.0%(12/40);因鱼腥草注射液病死5例,占12.5%(5/40);因丹参注射液发生胸闷、呼吸困难9例,占22.5%(9/40);因红花注射液导致患者出现红疹、心慌8例,占20.0%(8/40);因艾迪注射液造成休克6例,占15.0%(6/40)。结论临床对于中药注射剂配伍时,应选择适宜的溶媒配伍,加强配伍操作的规范化和合理化,以提高中药注射剂配伍的安全性。
Objective To explore the reasons for incompatibility of traditional Chinese medicine injections with other drugs and their countermeasures. Methods Forty patients with adverse reactions of traditional Chinese medicine injections published from the official website of the food and drug administration from January 2013 to October 2014 were selected as the research objects. According to the types of traditional Chinese medicine injections and compatibility of the types of drugs used in all patients with Chinese medicine injection statistics, classification and detailed analysis to observe the reasons for the incompatibility occurs, and propose appropriate solutions. Results In 40 patients, dizziness and nausea occurred in 12 cases, accounting for 30.0% (12/40) due to Qingkailing injection; 5 cases died of Houttuynia injection (12.5%, 5/40) Liquid occurred chest tightness, dyspnea in 9 cases, accounting for 22.5% (9/40); due to safflower injection patients lead to rash, palpitation in 8 cases, accounting for 20.0% (8/40); Aidi injection caused by shock 6 Cases, accounting for 15.0% (6/40). Conclusion Clinical compatibility of traditional Chinese medicine injection, should choose the appropriate compatibility of the solvent to enhance the standardization of compatibility and rationalization in order to improve the compatibility of traditional Chinese medicine injection safety.