Background:The relationship between physical and psychopathological features in complex regional pain syndrome(CRPS) has been a subject of constant interest,but no data are available in adolescents.Therefore,we aimed to identify the factors associated with psychopathology in adolescents with CRPS ahead of military service.Methods:We retrospectively reviewed all conscription examinees who had completed a Military Personality Inventory(MPI) during a period between February 2013 and December 201.6.A total of 63 persons with a history of CRPS(19-years of age for all) were enrolled.Basic demographic and pain-related data were analyzed to examine their association with MPI results.The mean FGR score as well as the 8 subdomain scores were compared between those with pain duration at ＜15 months (n=30) vs.≥15 months (n=33).Binary MPI results (normal-abnormal) were also compared between the two groups.Results:In multivariate analysis,abnormal MPI was associated with pain duration,with an odds ratio (OR) at 1.05 for every 1-month increase[95％ confidence interval (CI) 1.02-1.08;P=0.002].SubJects with pain duration at ≥15 months have lower faking good response score (P＜0.001 vs.those with pain duration at ＜15 months),and higher abnormal MPI result rate,faking bad response,inconsistency,anxiety,depression,somatization,paranoid,personality disorder cluster A,and personality disorder cluster B scores (P＜0.05).Pain duration was significantly associated with the MPI variables.Conclusions:Pain duration is associated with psychopathology in adolescents with CRPS.Psychopathologic features increased as the disease duration increased.A comprehensive understanding of time-dependent psychopathological factors could support the planning of multimodal approaches for managing adolescent CRPS.