目的　研究白细胞介素 2受体和糖皮质激素受体在大鼠脑内的分布及两者共存的可能性。　方法　免疫细胞化学双重标记技术 (PAP法与ABC法相结合 ) ,分别采用DAB和DBHC(二盐酸联苯胺 )呈色 ,前者为棕黄色 ,后者为深蓝色。　结果　白细胞介素 2受体和糖皮质激系受体广泛分布于大脑皮质、海马、下丘脑 ,脑干大部分运动性和感觉性核团。白细胞介素 2受体免疫反应产物位于细胞膜上 ;糖皮质激素受体免疫反应产物位于细胞核和胞浆内。脑内有较多的白细胞介素 2受体和糖皮质激素受体共存的神经元 ,它们在阳性神经元总数中所占的比例在不同的脑区有所不同。在大脑皮质约占 5 0 % ,在展神经核约占 30 %。　结论　免疫细胞因子和激素可通过各自的受体作用于同一个脑神经元而调节神经元的功能。本实验在受体水平为“免疫 神经 内分泌调节网络”学说提供了形态学证据 Objective To study the distribution of interleukin 2 receptor and glucocorticoid receptor in rat brain and the possibility of their co-existence. Methods Immunocytochemical double labeling (PAP method combined with ABC method), respectively, using DAB and DBHC (benzidine dihydrochloride) coloring, the former is brown, the latter is dark blue. Results Interleukin 2 receptor and glucocorticoid receptor were widely distributed in most motor and sensory nuclei in cerebral cortex, hippocampus, hypothalamus and brain stem. Interleukin 2 receptor immuno-reaction product is located on the cell membrane; glucocorticoid receptor immune response product is located in the nucleus and cytoplasm. There are more neurons in the brain coexisting with interleukin 2 receptor and glucocorticoid receptor, and their proportion in the total number of positive neurons varies in different brain regions. About 50% in the cerebral cortex, nerve fibers in the exhibition about 30%. Conclusion Immune cytokines and hormones can regulate the function of neurons by acting on the same brain neurons through their receptors. This experiment provides morphological evidence at the receptor level as the “neuroendocrine regulatory network” theory