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目的分析《中华人民共和国卫生部药品标准·中药成方制剂》(以下简称《中药部颁标准》)含生地黄方剂组方规律,为临床应用及新药研发提供参考。方法借助中医传承辅助平台(V2.0)软件,对《中药成方制剂》中含有生地黄方剂收集整理,构建数据库,采用关联规则、改进的互信息法等数据挖掘方法,分析其主治疾病、证候规律及常用配伍组合。结果含有生地黄方剂共357首,常用药物组合17个;主治疾病22种,对其中2种高频疾病“不寐”、“眩晕”常用药组合对比分析,显示生地黄不同配伍治疗作用不同。结论《中药部颁标准》中含生地黄方剂所用药物多具有清热凉血、养阴生津功效,用药较为集中,组方法度清晰;用药规律反映了生地黄治疗不同疾病时的配伍特点,为充分发挥生地黄的功效及临证科学组方提供依据。
Objective To analyze the regularities of prescriptions of “Rehmanniae Decoction” (hereinafter referred to as the “Standard of Chinese Pharmacopoeia”) of “Drug Standards of People’s Republic of China Ministry of Health, Chinese Pharmacopoeia” to provide reference for clinical application and research and development of new drugs. Methods The Traditional Chinese Medicine Prescriptions (TCM) preparations were collected and sorted with the aid of the software of TCM inheritance assistant platform (V2.0), and a database was constructed. Data mining methods such as association rules and improved mutual information method were used to analyze the main diseases, Syndromes and commonly used combination of law. Results The results showed that there were 357 first half prescriptions of Radix Rehmanniae and 17 commonly used drugs. Among them, 22 were the main diseases, and the comparative analysis of two common high frequency diseases, “insomnia” and “dizziness” Different treatment. Conclusion The prescriptions of Dihuang Recipe contained in the Standard of Chinese Materia Medica have the functions of clearing away heat and cooling blood and nourishing yin and invigorating the body. Drugs are more concentrated and the methods of group prescription are clear. The medication rules reflect the compatibility characteristics of Radix Rehmanniae Preparata when treating different diseases, Give full play to the effectiveness of Rehmannia and clinical evidence to provide scientific basis.