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重型肝炎有凝血机制的障碍,肝素的使用将进一步加重凝血功能的紊乱。目前国内人工肝治疗肝素用量大小不一,很多单位往往依据经验或血液透析的用量。肝素用量不足将导致管路凝血,影响治疗顺利进行,肝素用量过大将加重出血倾向,甚至带来严重后果。本研究通过实时监测人工肝血浆置换时患者凝血功能的变化状况并随时调整肝素的用量,保证了治疗的安全顺利进行,并为重型肝炎患者人工肝体外循环肝素的规范应用提供了依据。一、资料与方法1.病例选择:2004年1月至4月,在首都医科大学附属北
Hepatic hepatitis has a clotting mechanism of obstacles, the use of heparin will further aggravate coagulation disorders. Currently the amount of heparin in the treatment of artificial liver varies in size, many units are often based on experience or the amount of hemodialysis. Inadequate dosage of heparin will lead to coagulation of the pipeline, affecting the smooth progress of treatment, excessive use of heparin will increase bleeding tendency, and even serious consequences. In this study, through real-time monitoring of coagulation changes in patients with artificial liver plasma exchange and the timely adjustment of the amount of heparin to ensure the safe and successful treatment, and provide a basis for the standard application of artificial hepatic extrahepatic heparin in patients with severe hepatitis. First, the data and methods 1. Case selection: January 2004 to April, Capital Medical University Affiliated North