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目的:研究山葛降脂分散片中葛根素在大鼠体内的组织分布。方法:以香草醛为内标物,采用HPLC法测定大鼠各组织中葛根素的含量。结果:按175.6mg(葛根素)/kg大鼠体重灌胃山葛降脂分散片后,葛根素在其体内分布广泛,以心、肝、肾中分布较高,各组织中葛根素的含量于给药后2h最高4,h后显著下降,12h后基本消除。结论:山葛降脂分散片中葛根素在大鼠体内分布快且广泛,消除也快,且可穿越血脑屏障。
Objective: To study the tissue distribution of puerarin in Shange Jiangzhi Jiangzhi Dispersible Tablets in rats. Methods: Vanillin was used as the internal standard. The content of puerarin in each tissue was determined by HPLC. Results: Puerarin was widely distributed in the body after oral administration of Shange Jiangzhi Jiangzhi Dispersible Tablets at a body weight of 175.6mg / kg, with a high distribution in heart, liver and kidney. The content of puerarin in each tissue 2h after administration of up to 4, h after a significant decline, 12h after the basic elimination. Conclusion: Puerarin in Shange lipid-lowering dispersible tablets is fast and widely distributed in rats and can be eliminated quickly, and can cross the blood-brain barrier.