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为研究IL-33在儿童急性免疫性血小板减少症(ITP)发病机制中的作用及意义,我们采用ELISA法检测了37名ITP患儿和37名对照者血清IL-33水平,分析IL-33与患儿就诊时血小板计数及后期疗效的关系。我们发现,ITP患儿血清IL-33较对照者明显增高(P<0.01),且与血小板计数呈负相关(R2=0.10,P=0.05)。血清IL-33水平与治疗效果密切相关,采用IL-33预测ITP患儿疗效,预测敏感性为0.88,特异性为0.81。这些结果提示:IL-33参与了ITP的发病机制,血清IL-33水平可以作为预测患儿疗效的免疫学指标。
To investigate the role and significance of IL-33 in the pathogenesis of childhood acute thrombocytopenia (ITP), we measured serum levels of IL-33 in 37 ITP children and 37 controls by ELISA and analyzed the levels of IL-33 Relationship with Platelet Count and Postoperative Efficacy in Treatment of Children. We found that IL-33 levels in children with ITP were significantly higher than those in controls (P <0.01) and negatively correlated with platelet counts (R2 = 0.10, P = 0.05). The level of serum IL-33 is closely related to the therapeutic effect. The efficacy of IL-33 in predicting the ITP children is predicted with a sensitivity of 0.88 and a specificity of 0.81. These results suggest that IL-33 is involved in the pathogenesis of ITP. Serum IL-33 level can be used as an immunological indicator to predict the therapeutic effect in children.