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糖尿病以慢性高血糖为主要共同特征,高血糖是心血管疾病进展的独立的危险因素。糖尿病人群中动脉粥样硬化性疾病的患病率高、发病年龄较轻、病情进展快、多脏器同时受累较多。高血糖致血管内皮受损是动脉粥样硬化的重要原因之一;因而增加胰岛β细胞数量、改善胰岛β细胞功能,降低血糖;保护血管内皮细胞;可抑制动脉粥样硬化的进展,减少糖尿病心血管并发症。而肝细胞生长因子(HGF)是由间质细胞产生的多效性生长因子,能刺激多种类型的细胞分化、增殖、运动、迁移、促进新生血管形成;在糖尿病及心血管并发症的诊断和治疗中具有重要作用。本文就HGF对胰岛β细胞、血管内皮细胞和在心肌梗死中的具体作用及机制综述如下。
Diabetes with chronic high blood sugar as the main common features, high blood sugar is an independent risk factor for the progression of cardiovascular disease. The prevalence of atherosclerotic disease in diabetic population is high, the age of onset is relatively mild, the condition progresses rapidly, and multiple organ involvement is more at the same time. Hyperglycemia caused by vascular endothelial damage is an important cause of atherosclerosis; thereby increasing the number of pancreatic β-cells, improve pancreatic β-cell function and lower blood glucose; protect vascular endothelial cells; can inhibit the progression of atherosclerosis and reduce diabetes Cardiovascular complications. Hepatocyte growth factor (HGF), a pleiotropic growth factor produced by interstitial cells, can stimulate many types of cell differentiation, proliferation, movement, migration and promote neovascularization. In the diagnosis of diabetes and cardiovascular complications And treatment plays an important role. This article HGF on islet β cells, vascular endothelial cells and myocardial infarction in the specific role and mechanism are summarized below.