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为了探讨香烟烟雾中的有害成份——氧化碳(CO)对长期吸烟者血液流变学的影响,我们对122名健康男性(60名长期吸烟者、62名不吸烟者)的血气及血液流变与学指际进行了比较研九。结果显示:吸烟组的碳氧血红蛋白水平(COHb)是对照组的2.84倍,且总血红蛋白水平(THb)、红细胞压积(Het)、切变率为230S~(-1)和235~(-1)吋的全血粘度均较对照组显著增高。逐步回归分析显示:吸烟情况化码依次与红细胞压积、血浆粘度、碳氧血红蛋白水平相关.表明吸烟是导致这些指标变化的原因;面全血粘度依次依与红细胞压积、血浆粘度相关,则表明这些因子是直接引起血液粘度增高的决定因素;碳氧血红蛋白水平分別与红细胞压积、全血粘度相关,提示香烟烟雾中的一氧化碳引起红细胞压积的增高,是长期吸烟者血液粘度升高的重要原因。
To investigate the effect of carbon monoxide (CO), a harmful component of cigarette smoke, on the hemorheology of long-term smokers, we investigated the blood gas and blood flow in 122 healthy men (60 long-term smokers and 62 non-smokers) Comparative study with the study conducted nine. The results showed that the level of carboxyhemoglobin (COHb) in smoking group was 2.84 times that of control group, and the total hemoglobin level (THb), hematocrit (Het), shear rate of 230S ~ (-1) and 235 ~ 1) inches of whole blood viscosity were significantly higher than the control group. Stepwise regression analysis showed that the smoking pattern codes were related to hematocrit, plasma viscosity and carboxyhemoglobin level, which indicated that smoking was the reason for the changes of these indexes. The relationship between total blood viscosity and hematocrit and plasma viscosity was Indicating that these factors are the direct determinants of increased blood viscosity; carboxyhemoglobin levels were associated with hematocrit, whole blood viscosity, suggesting that carbon monoxide in cigarette smoke caused by increased hematocrit, blood viscosity in long-term smokers important reason.