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目的 :探讨老年急性心肌梗死 (AMI)患者肿瘤坏死因子 -α(TNF -α)、白细胞介素 -6(IL 6)、一氧化氮(NO)的变化与发病的关系。方法 :测定 4 0例老年急性AMI患者TNF α、NO浓度及IL 6活性 ,并以 30例健康老年人作为对照。结果 :老年AMI患者与健康老年对照组比较 ,其发病 2 4h内血浆TNF α含量、IL 6生物活性均高于对照组 (P <0 .0 5)。NO浓度较对照组显著降低 (P <0 .0 5)。且发病 2 4h内心功能Ⅲ～Ⅳ级者TNF -α浓度较心功能Ⅰ～Ⅱ级者高 (P <0 .0 5) ,NO含量低于心功能Ⅰ～Ⅱ级者 (P <0 .0 5) ,而IL 6活性两组间差异无显著意义。 (P <0 .0 5)。结论 :TNF α、IL 6、NO均参与了老年AMI的发病过程。
Objective: To investigate the relationship between the changes of tumor necrosis factor-α (TNF-α), interleukin-6 (IL 6) and nitric oxide (NO) in elderly patients with acute myocardial infarction (AMI) Methods: The levels of TNFα, NO and IL-6 in 40 elderly patients with acute AMI were measured and 30 healthy controls were used as controls. Results: Compared with healthy control group, the plasma levels of TNFα and the activity of IL-6 in the elderly AMI patients were significantly higher than those in the control group within 24 hours of onset (P <0.05). NO concentration was significantly lower than the control group (P <0. 05). The TNF-αlevel of heart functionⅢ-Ⅳlevel was higher than that of heart functionⅠ-Ⅱlevel (P <0.05), and the content of NO was lower than that of heart function Ⅰ-Ⅱlevel (P <0. 0) 5), while there was no significant difference between the two groups in IL 6 activity. (P <0. 05). Conclusion: TNF α, IL 6 and NO are all involved in the pathogenesis of AMI in the elderly.