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近十几年,学者们做了大量工作,试图应用维甲类来抑制各种器官的癌前变化和癌变过程。现将有关研究资料简要综述于下。一、气管和肺使用维生素甲抑制肺癌形成的动物实验开展比较早。Saffiotti用金黄地鼠作实验,由气管注入3毫克苯并芘和3毫克三氧化二铁,共10次。一组不继续处理。结果:34%产生鳞状上皮化生,21%发生鳞癌;另一组在用苯并芘处理后一周开始,每周接受二次维生素甲(5毫克溶于0.1毫升玉米油)胃管注入,结果:鳞状上皮化生出现率为4%,鳞癌只一例,占2%。该作者认为维生素甲能抑制呼吸道粘膜柱状上皮的鳞状化生和鳞癌的形成。之后,Grocker等培养哺乳期的地鼠气
In the past decade or so, scholars have done a lot of work and tried to use retinoids to inhibit the precancerous changes and carcinogenesis of various organs. The relevant research materials are briefly summarized below. First, the use of vitamin A in the trachea and lungs to inhibit the formation of lung cancer is relatively early in animal experiments. Saffiotti used a golden hamster as an experiment to infuse 3 mg of benzopyrene and 3 mg of ferric oxide from the trachea for 10 times. One group does not continue processing. Results: 34% developed squamous metaplasia and 21% developed squamous cell carcinoma; the other group began a week after treatment with benzopyrene and received twice weekly vitamin A (5 mg dissolved in 0.1 ml corn oil) into the stomach. RESULTS: The rate of squamous metaplasia was 4%, and squamous cell carcinoma was only one case, accounting for 2%. The authors believe that vitamin A can inhibit the squamous metaplasia and squamous cell carcinoma formation in the respiratory mucosal columnar epithelium. Later, Grocker et al. cultivate lactating hamsters