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目的探讨子宫内膜异位症相关性卵巢癌(endometriosis associated ovarian cancer,EAOC)组织中P53和survivin蛋白表达水平。方法 64例EAOC患者为EAOC组,50例女性体检健康者为对照组,应用免疫组织化学SP法检测2组子宫内膜组织P53、survivin蛋白的表达情况;比较EAOC不同临床分期P53和survivin蛋白的阳性指数(positive index,PI)差异。结果 EAOC组P53、survivin蛋白阳性率(64.06%、59.38%)高于对照组(0、0)(P<0.05);EAOC临床Ⅰ、Ⅱ、Ⅲ、Ⅳ期P53的PI值分别为78.3±4.7、88.2±4.3、92.7±3.4、98.3±1.4,survivin蛋白的PI值分别为79.4±6.2、87.5±4.4、90.2±2.3、96.6±1.5,不同病理分期PI值比较差异均有统计学意义(P<0.05)。结论 EAOC患者P53及survivin蛋白阳性表达率增高,P53及survivin蛋白对EAOC的发展有协同作用。
Objective To investigate the expression of P53 and survivin protein in endometriosis-associated ovarian cancer (EAOC) tissues. Methods 64 patients with EAOC were selected as EAOC group and 50 healthy women as control group. The expression of P53 and survivin protein in endometrial tissue of two groups were detected by immunohistochemical SP method. The expressions of P53 and survivin protein in different clinical stages of EAOC Positive index (positive index, PI) difference. Results The positive rates of P53 and survivin in EAOC group were significantly higher than those in control group (64.0%, 59.38%) (P <0.05). The PI values of P53 in stage Ⅰ, Ⅱ, Ⅲ and Ⅳ of EAOC were 78.3 ± 4.7 , 88.2 ± 4.3, 92.7 ± 3.4, 98.3 ± 1.4, respectively. The PI of survivin protein were 79.4 ± 6.2, 87.5 ± 4.4, 90.2 ± 2.3 and 96.6 ± 1.5 respectively, and there were significant differences in the PI value of different pathological stages (P <0.05). Conclusions The positive rate of P53 and survivin protein in patients with EAOC is increased, and the expression of P53 and survivin proteins have a synergistic effect on the development of EAOC.