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目的分析结肠癌患者术前血清前白蛋白(PA)、白蛋白(ALB)、胆碱酯酶(CHE)的水平及其临床意义。方法收集307例结肠癌首诊患者及380例健康体检者血清ALP、ALT、AST、ADA、GGT、CHE、TP、ALB、PA实验室检测结果,并进行统计分析。结果结肠癌患者较健康体检者血清PA、ALB和CHE水平显著降低,差异具有统计学意义(P<0.01);双变量相关性分析显示,血清PA、ALB和CHE水平与结肠癌呈负相关,相关系数(r)分别为-0.64、-0.64、-0.53,差异具有统计学意义(P<0.01);多因素Logistic回归分析显示,血清PA、ALB和CHE水平在结肠癌发生中的相对危险度OR(95%CI)分别是0.33(0.25~0.43)、0.40(0.30~0.56)和0.71(0.55~0.91),差异具有统计学意义(P<0.01);然而,PA、ALB和CHE水平与结肠癌转移及分化程度无明显关系。结论血清CHE、ALB、PA水平与结肠癌呈负相关,可作为检测结肠癌的标志物。
Objective To analyze the preoperative serum albumin (PA), albumin (ALB) and cholinesterase (CHE) in patients with colon cancer and its clinical significance. Methods The laboratory test results of serum ALP, ALT, AST, ADA, GGT, CHE, TP, ALB and PA in 307 first colon cancer patients and 380 healthy controls were collected and analyzed statistically. Results Serum levels of PA, ALB and CHE in patients with colon cancer were significantly lower than those in healthy controls (P <0.01). Bivariate correlation analysis showed that serum PA, ALB and CHE levels were negatively correlated with colon cancer, The correlation coefficients (r) were -0.64, -0.64, -0.53, respectively, with significant difference (P <0.01). Multivariate Logistic regression analysis showed that the relative risk of PA, ALB and CHE in colon cancer OR (95% CI) were 0.33 (0.25-0.43), 0.40 (0.30-0.56) and 0.71 (0.55-0.91) respectively, with statistical significance (P <0.01). However, the levels of PA, There was no significant correlation between the degree of cancer metastasis and the degree of differentiation. Conclusions Serum levels of CHE, ALB and PA are negatively correlated with colon cancer and may be used as markers for detecting colon cancer.