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研究8名正常成年人苯妥英钠在不同给药途径即静脉注射、肌肉注射和口服时的绝对生物利用度及药物代谢动力学。肌肉注射的生物利用度比口服为低,峰值仅为口服的三分之一左右。
To study the absolute bioavailability and pharmacokinetics of phenytoin in 8 normal adults under different routes of administration, ie intravenous injection, intramuscular injection and oral administration. The bioavailability of intramuscular injection is lower than that of oral administration, and the peak is only about one-third of oral.