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Visfatin是一种在内脏脂肪组织高表达的脂肪细胞因子,具有类胰岛素、调节免疫及炎症、促进脂肪分化及合成等多重生物学作用。目前普遍认为肥胖及2型糖尿病(T2DM)等代谢性疾病均伴随低度系统性慢性炎性反应,而visfatin可能是联系炎症及代谢性疾病的环节之一。深入研究vis-fatin与炎症的关系可能为T2DM及肥胖的治疗提供新靶点。
Visfatin is a kind of adipocytokine that is highly expressed in visceral adipose tissue. It has multiple biological functions such as insulin-like, immune regulation, inflammation, fat differentiation and synthesis. It is generally accepted that metabolic diseases such as obesity and type 2 diabetes (T2DM) are associated with a low degree of systemic chronic inflammatory response, and visfatin may be one of the links between inflammation and metabolic diseases. In-depth study of the relationship between vis-fatin and inflammation may provide a new target for the treatment of T2DM and obesity.