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目的 :为评估湛江市吸毒人群 HCV、HBV的感染状况 ,以及吸毒合并 HCV、HBV感染对血清 AL T异常的影响。方法 :收集 2 0 0 2 - 0 2～ 2 0 0 3- 0 3湛江市吸毒人群资料 ,并对调查对象进行血清 HCV、HBV和 AL T的检测。结果 :湛江市静脉吸毒人群的 HBs Ag阳性率、HCV感染率和 HBV感染率分别为 2 4 .6 1%、5 7.87%、6 7.32 % ,明显高于对照组(11.0 3%、0 .91%、5 1.96 % ) ,有显著性差异 ,非静脉吸毒组此 3项与对照组比较无显著性差异 ;HBV单项、HCV单项、HBV和 HCV混合项 ,这 3种组合感染的静脉吸毒者 ,他们血清中的 AL T异常率分别为 15 .6 9%、33.33%、4 5 .5 0 % ,这3种 AL T异常率分别与未感染 HBV、HCV的静脉吸毒者的 AL T异常率 (9.84 % )比较 ,前者无显著性差异 ,后两者有显著性差异。结论 :静脉吸毒是吸毒者感染 HBV、HCV的重要途径 ;HCV感染对静脉吸毒者血清 AL T的异常起重要作用
Objective: To evaluate the status of HCV and HBV infection among drug addicts in Zhanjiang City and the effect of drug addicted HCV and HBV infection on the abnormality of serum ALT. Methods: The data of drug addicts from 2000-2002 ~ 2000-2003 in Zhanjiang were collected, and the levels of HCV, HBV and ALT in serum were detected. Results: The positive rates of HBsAg, HCV infection and HBV infection in intravenous drug users in Zhanjiang were 24.61%, 5 7.87% and 6 7.32%, respectively, which were significantly higher than those in the control group (11.0 3%, 0.91 %, 5 1.96%), there was a significant difference between the three non-intravenous drug use group and the control group no significant difference; HBV single, HCV single, HBV and HCV mixed items, these three combinations infected intravenous drug users, The ALT abnormalities in their serum were 15.69%, 33.33% and 45.5% respectively. The abnormal rates of AL T abnormalities in these three kinds of ALT were significantly higher than those in non-infected HBV and HCV 9.84%) compared with the former no significant difference, the latter two significant differences. Conclusion: Intravenous drug use is an important route of infection of HBV and HCV among drug users. HCV infection plays an important role in the abnormality of serum ALT in intravenous drug users