注入人体的输液中含有热原量如达到1μg/kg就可导致热原反应,这对人体危害极大,可引起患者高烧、昏迷,甚至死亡。因此在制备大输液的成品中绝对不允许有热原存在。过去认为热原耐高温,必须经250℃30分钟或180℃2个小时的干热高温处理,才能有效地除去。近年来有报道则认为;热原的耐热性是相对的,尤其是在水溶液里热原的活性,耐热性均降低,在酸硷介质中更不稳定。 Infusion into the human body containing the amount of heat if the amount of 1μg / kg can lead to pyrogen reaction, which is extremely harmful to humans, can cause patients with high fever, coma and even death. Therefore, the preparation of large transfusion in the final product is absolutely not allowed to have pyrogen. In the past that pyrogen high temperature, must be 250 ℃ 30 minutes or 180 ℃ 2 hours of hot and dry heat treatment, can effectively remove. In recent years, it has been reported that pyrogen is relatively heat-resistant, especially in aqueous solution pyrogen activity, heat resistance are reduced in acid medium more unstable.