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本实验选择日本大耳白兔,采用动脉内膜剥脱并喂养高胆固醇饲料的方法,建立兔髂动脉粥样硬化狭窄模型。结果显示:兔血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)降低,而高密度脂蛋白胆固醇(HDL-C)增高,血栓素 B_2(TXB_2)/6-酮-前列腺素 F_(1α)(TXB_2/6-k-PGF_(1α))增高。说明动脉粥样硬化的发生与内膜的损伤、脂代谢紊乱和 TXA_2/PGI_2失平衡有关。36只兔右髂动脉狭窄46处,主要是向心性局限性狭窄,程度为69%±25%,镜下可见内膜增厚,内有大量的脂质和泡沫细胞,胶原纤维和弹力纤维,以及平滑肌细胞。这种新的模型具有三个特点:(1)选用日本大耳白兔而不是新西兰家兔。(2)用球囊扩张导管代替 Forgaty 导管剥脱内膜。(3)胆固醇用量明显减少,每天只给0.5g。
The experiment selected Japanese white rabbits, the use of arterial endarterectomy and feeding of high cholesterol feed method, the establishment of rabbits iliac artery atherosclerosis stenosis model. The results showed that the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL- 6-keto-prostaglandin F_ (1α) (TXB_2 / 6-k-PGF_ (1α)) increased. That the occurrence of atherosclerosis and intimal damage, lipid metabolism and TXA 2 / PGI 2 imbalance. 36 rabbits with right iliac artery stenosis 46, mainly to the limitations of cardiac stenosis, the degree of 69% ± 25%, endometrial thickening can be seen under microscope, there are a large number of lipid and foam cells, collagen fibers and elastic fibers, As well as smooth muscle cells. This new model has three characteristics: (1) the selection of Japanese white rabbits instead of New Zealand rabbits. (2) Exfoliate the intima with a balloon dilatation catheter instead of a Forgaty catheter. (3) significantly reduced the amount of cholesterol, only 0.5g per day.