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目的:通过检测幽门螺杆菌(HP)患者血清中细胞毒素相关蛋白(CagA)、尿素酶(UreC)、热休克蛋白(HSP60)的抗体谱,探讨HP感染的消化道疾病患者在不同年龄组的分布及种类的差异。方法:采用蛋白芯片方法对457例临床患者HP血清进行检测。结果:检测出HP阳性率为89.72%,高于广州地区(63.1%),其中老年组检测率最高为91.59%。老年组UreC抗体阳性率为74.30%,高于儿童组和青年组,差异有统计学意义。CagA、UreC感染的毒力株以青年组为主,高于儿童组和老年组。结论:提示HP感染的青年组以UreC、Ca-gA为主,老年组以UreC和UreC、HSP60为主。通过筛查不同的抗体类型,可为临床诊断治疗消化道疾病提供重要的指导意义。
OBJECTIVE: To detect the antibody spectrum of CagA, UreC and HSP60 in the serum of patients with Helicobacter pylori (HP), and to investigate the relationship between HP-infected patients with gastrointestinal diseases in different age groups Distribution and types of differences. Methods: 457 clinical serum samples were tested by protein chip method. Results: The positive rate of HP was 89.72%, which was higher than that of Guangzhou (63.1%). The highest detection rate in elderly group was 91.59%. The positive rate of UreC antibody in elderly group was 74.30%, which was higher than that in children group and youth group, the difference was statistically significant. The virulent strains infected with CagA and UreC were mainly young group and higher than those of children group and old group. Conclusion: UreC and Ca-gA are the main risk factors of HP infection in young people. UreC, UreC and HSP60 are the main factors in elderly patients. Screening for different antibody types can provide important guidance for clinical diagnosis and treatment of gastrointestinal diseases.