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目的：研究应用急性病理生理学和长期健康评价（APACHE）Ⅱ评估慢性阻塞性肺疾病急性加重期（AECOPD）行有创机械通气患者预后的价值。方法回顾性分析2010年1月～2013年12月收住急诊内科的180例AECOPD行机械通气支持治疗的患者临床资料，研究患者收入急诊内科24 h内的APACHEⅡ评分结果，以多元回归方程计算预计病死率并与患者实际病死率进行比较，判断其与预后的关系。结果共纳入180例患者，其APACHEⅡ评分为平均19.1分；随着APACHEⅡ评分增高，患者实际病死率及预计病死率均逐渐增高且体现出一定的相关性。结论APACHEⅡ评分可用于AECOPD行机械通气患者预后评估，对临床治疗具有指导意义。“,”Objective To study the value of applying APACHEⅡ to the prognosis evaluation of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) receiving the invasive mechanical ventilation. Methods A retrospective analysis was made in the clinical data of 180 patients with AECOPD receiving the invasive mechanical ventilation in Emergency Internal Medicine of our hospital from January 2010 to December 2013. Research was carried out on the correlation between the APACHEⅡscores of these cases 24 hours within the admission in Emergency Internal Medicine and their prognosis by using multiple regression equation. Results Totally 180 patients were involved. The average APACHEⅡscore was 19.1 points. Along with the increase of the APACHEⅡscore, actual case fatality and expected mortality in the patients gradually increased. Conclusion APACHEⅡscore can be used in the prognosis evaluation of patients with AECOPD receiving the invasive mechanical ventilation because of the mutual correlation. It has guiding significance for the clinical treatment.