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目的 :观察肝康合剂对大鼠四氯化碳性肝纤维化的防治效果。方法 :40 %四氯化碳花生油给予大鼠皮下注射诱导肝纤维化 ,肝康合剂干预 ,秋水仙碱对照。分别在 3周末及 6周末取血、取肝脏 ,放免法测量 HA、L N、PC- ,并通过光镜观察肝组织病理变化。结果 :3周时 ,肝康合剂组大鼠血清 HA、PC- 明显低于模型组 ( P<0 .0 5) ,L N降低但无差异性 ( P>0 .0 5)。6周时 ,肝康合剂组血清学指标、肝纤维化程度均好于模型组 ( P<0 .0 5) ,与正常组无差异 ( P>0 .0 5)。结论 :肝康合剂组具有良好的防治肝纤维化作用。
Objective: To observe the preventive and therapeutic effects of Gankanghe mixture on carbon tetrachloride-induced hepatic fibrosis in rats. METHODS : 40% carbon tetrachloride peanut oil was injected subcutaneously into rats to induce hepatic fibrosis, liver-Kang mixture intervention, and colchicine control. Blood was collected at 3 weekends and 6 weekends, livers were harvested, and HA, LN, and PC- were measured by radioimmunoassay. The pathological changes of liver tissue were observed by light microscopy. RESULTS: At 3 weeks, serum HA and PC- were significantly lower in the liver Kang mixture group than in the model group (P<0.05), but the LN decreased but there was no difference (P>0.05). At 6 weeks, the serum markers and hepatic fibrosis were significantly better in the Gankang Mixture group than in the model group (P<0.05), but not in the normal group (P>0.05). Conclusion : The combination of liver and Kangkang has a good effect on prevention and treatment of hepatic fibrosis.