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Tim-3 Signaling Determines Intestinal Homeostasis and Diseases by Regulating Macrophage Polarization
[会议论文] 作者：Gencheng HAN,Yan LI,Beifen SHEN,
来源：第十六届中国科协年会 年份：2014
We previously found that T cell immunoglobulin and mucin domain protein 3 (Tim-3) signaling contributed to intestinal homeostasis while the underlying mechanisms remain unclear.Here we demonstrate tha...
[会议论文] 作者：Jiyan Zhang,Beifen Shen,Anning Lin,
来源：第一届世界华人免疫学大会(International Conference on Immunology 2007) 年份：2007
...
[会议论文] 作者：Kun Han,Qingyang Wang,Beifen Shen,Jiyan Zhang,
来源：The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会) 年份：2015
T-cell acute lymphoblast leukemia (T-ALL) is usually a highly aggressive non-Hodgkins lymphoma and most patients die within one year of diagnosis.Thus, it is urgent to find an effective way of cure.In...
Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma
[会议论文] 作者：Jing Wang,Ruihong Tang,Ming Lv,Jiyan Zhang,Beifen Shen,
来源：2010中国青年遗传学家论坛 年份：2010
Background: The cyclic AMP (cAMP) signaling pathway has been reported to either promote or suppress cell death, in a cell context-dependent manner.Our previ...
[会议论文] 作者：Dan Liu,Ming Shi,Huijun Duan,Beifen Shen,Ning Guo,
来源：中国细胞生物学学会全体会员代表大会暨第十二次学术大会 年份：2011
In the present study, β2-AR level was found to be up-regulated in MCF-7 cells overexpressing Her2 (MCF-7/Her2).Correlation of β2-AR level with Her2 status was demonstrated in breast cancer tissue samp...
A ROLE FOR THE AUTOINHIBITORY DOMAIN OF PHOSPHOLIPASE GAMMA 2 IN STABILIZING EARLY B CELL RECEPTOR S
[会议论文] 作者：Jing Wang,Susan K.Pierce,Joshua D.Milner,Haewon Sohn,Beifen Shen,Jiyan Zhang,
来源：The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会) 年份：2015
...
The comparison of BLyS-binding peptides from phage display library and computer-aided design on BLyS
[会议论文] 作者：Yacong Zhao,Xiafei Hao,Jiannan Feng,Beifen Shen,Jing Wei,Jian Sun,
来源：第八届国际分子模拟与信息技术应用学术会议 年份：2016
BLyS antagonists have become the therapeutic reagents in the treatment of autoimmune disorders.BLyS binding peptides and their Fc fusion proteins may be altemative BLyS antagonists in Such application...
A ROLE FOR THE AUTOINHIBITORY DOMAIN OF PHOSPHOLIPASE GAMMA 2 IN STABILIZING EARLY B CELL RECEPTOR S
[会议论文] 作者：Jing Wang,Haewon Sohn,Joshua D.Milner,Beifen Shen,Susan K.Pierce,Jiyan Zhang,
来源：The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会) 年份：2015
Antigen binding to the B cell receptor (BCR) triggers the assembly of a signaling complex composed initially of the kinases Lyn, Syk, and Btk and the adaptor, BLNK, that together recruit and activate...
[会议论文] 作者：Wei Wang,Qingzhu Shi,Yuanfang Ma,Beifen Shen,Yan Li,Gencheng Han,
来源：中国免疫学会第十届全国免疫学学术大会 年份：2015
BACKGROUND&Aims: The NLRP3 inflammasome is a cytosolic multi-protein complex and assembled in response to both DAMP and PAMP....
[期刊论文] 作者：Ning Zhu,Jian Cui,Chunxia Qiao,Yan Li,Yuanfang Ma,Jiyan Zhang,Beifen Shen,
来源：中国免疫学杂志（英文版） 年份：2008
M-CSF is a key cytokine in macrophage development by inducing MAPKs activation, and cAMP can inhibit MAPKs activation induced by inflammatory stimuli. To explor...
[会议论文] 作者：Shusheng Geng,Shusheng Geng,Weisong Qin,Ming Lv,Yan Li,Jiannan Feng,Beifen Shen,
来源：第八届国际分子模拟与信息技术应用学术会议 年份：2016
The introduction of INF inhibitors has revolutionized the treatment of some chronic inflammatory diseases,e.g.,rheumatoid arthritis and Crohns disease.However,immunogenics ty is one of the important m...
[会议论文] 作者：Xingwei Jiang,Guojiang Chen,Renxi Wang,He Xiao,Chunmei Hou,Beifen Shen,Yan Li,Gencheng Han,
来源：中国免疫学会第九届全国免疫学学术大会 年份：2014
...
ERK-mediated induction of MKP-1 contributes to the inhibition by nocodazole of TNF--induced p38 acti
[会议论文] 作者：Xiangrui Guo,Yajing Li,Yuanyuan Guo,Jing Wang,Qingyang Wang,Beifen Shen,Dejun Sun,Jiyan Zhang,
来源：2010中国青年遗传学家论坛 年份：2010
The mitogen-activated protein kinase p38 plays key roles in cell progression, differentiation, inflammation, and apoptosis, p38 is activated by a variety of...
In vitro molecular evolution of anti-Her2 antibody MILS using an computer-aided epitope-specific syn
[会议论文] 作者：Chunxia Qiao,Ming Lv,Zhou Lin,Longlong Luo,Jing Geng,Yan Li,Jiannan Feng,Beifen Shen,
来源：第六届全国生物治疗学术大会 年份：2012
Increased affinities mainly equals to improved biological efficacy in many cases.By now display methods including phage library are widely exploited to obtain higher affinity antibodies.Traditional li...
[会议论文] 作者：Jianing Wang,Jiannan Feng,Ming Shi,Lu Qian,Liyong Chen,Ming Yu,Ruonan Xu,Beifen Shen,Ning Guo,
来源：第一届世界华人免疫学大会(International Conference on Immunology 2007) 年份：2007
...
Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-ce
[会议论文] 作者：Jian Cui,Qingyang Wang,Jing Wang,Ming Lv,Ning Zhu,Yan Li,Jiannan Feng,Beifen Shen,Jiyan Zhang,
来源：2010中国青年遗传学家论坛 年份：2010
Hyperactivation of c-Jun NH2-terminal protein kinase (JNK) has been found in various malignant lymphocytes and inhibition of JNK activity leads to cell cycl...
[会议论文] 作者：Jing Wang,Yujun Pei,Ting Zhu,Qingyang Wang,Ye Wu,Guihua Qiu,Dalin Zhang,Beifen Shen,Jiyan Zhang,
来源：中国免疫学会第十届全国免疫学学术大会 年份：2015
The JNK pathway has been implicated in mammary tumor development.However, the molecular mechanisms regulating JNK activity in breast cancer cells remain unc...
Affinity maturation of antiHER2 monoclonal antibody MIL5 using an epitope-specific synthetic phage l
[会议论文] 作者：Chunxia Qiao,Ming Lv,Xinying Li,Jing Geng,Yan Li,Jiyan Zhang,Zhou Lin,Jiannan Feng,Beifen Shen,
来源：第七届国际分子模拟与信息技术应用学术会议 年份：2014
Increased affinities mainly equal to improved biological efficacy in many cases.By now, display methods including phage library are widely exploited to obtain higher affinity antibodies.Traditional li...
[期刊论文] 作者：Hao Liu,Chunxia Qiao,Naijing Hu,Zhihong Wang,Jing Wang,Jiannan Feng,Beifen Shen,Yuanfang Ma,Longlong,
来源：工程（英文） 年份：2021
Immunotherapy with anti-programmed cell death protein-1(PD-1)/programmed cell death ligand-1(PD-L1)monoclonal antibodies has become routine in the treatment of many kinds of human cancers,such as lung cancer,intestinal cancer,and melanoma.T......
[期刊论文] 作者：Guang Yang,Yaping Gao,Jiannan Feng,Yong Huang,Shaohua Li,Yu Liu,Chuan Liu,Ming Fan,Beifen Shen,Ningsheng,
来源：生物化学与生物物理学报（英文版） 年份：2008
In Staphylococcus aureus, the target of RNAⅢ activating protein (TRAP) is a membrane-associated protein whose Cterminus can be used as a vaccine to provide pro...
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