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Effects of replacing a phosphorylation site with glutamate on the biological characteristics of huma
[会议论文] 作者：Chenyun Guo,Donghai Lin,
来源：第八届全国化学生物学学术会议 年份：2013
Raf kinase inhibitor protein (RKIP), belonging to the PEBP family, plays a pivotal modulatory role in several protein kinase signaling cascades.RKIP cross-modulates MAPK and GPCR pathways by phosphory...
[会议论文] 作者：Chenyun Guo,Donghai Lin,
来源：第八届全国化学生物学学术会议 年份：2013
Adenylate kinases are small monomeric enzymes which widely exist in a variety of organisms, from bacteria to mammals.AK1 mainly exists in more energy consuming organs.AK1 plays a crucial role in many...
[会议论文] 作者：Chenyun Guo,Zhihua Wu,Donghai Lin,
来源：中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 年份：2014
...
[会议论文] 作者：Chenyun Guo,Hanyu Chen,Donghai Lin,
来源：第5届中国结构生物学学术讨论会 年份：2016
...
[会议论文] 作者：Chenyun Guo,Zhihua Wu,Donghai Lin,
来源：中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 年份：2014
To analyze the backbone dynamics of AK1, we performed 15N relaxation measurementsusing NMR spectroscopy.Totally,115 assigned residues were used except the residueswith overlapping signals that were no...
[会议论文] 作者：Yuanhui Yu,Ziyao Yu,Chenyun Guo,Donghai Lin,
来源：第5届中国结构生物学学术讨论会 年份：2016
...
[会议论文] 作者：Donghai Lin,林东海,Chenyun Guo,郭晨云,
来源：第十七届全国波谱学学术会议 年份：2012
本文用结构生物学方法测定大鼠附睾中lipocalin家族蛋白的溶液结构、动力学及其与配体相互作用，研究它们在精子成熟过程中的生理功能和分子机理。研究表明这些Lipocalin蛋...
[期刊论文] 作者：Pei Huang,Fulin Lian,Yi Wen,Chenyun Guo,Donghai Lin,
来源：生物化学与生物物理学报（英文版） 年份：2013
...
,Biophysical characterization of oligomerization and fibrillization of the G131V pathogenic mutant o
[期刊论文] 作者：Meilan Zhang,Haoran Zhang,Hongwei Yao,Chenyun Guo,Donghai Lin,
来源：生物化学与生物物理学报（英文版） 年份：2019
The pathogenesis of fatal neurodegenerative prion diseases is closely associated with the conversion of α-helix-rich cellular prion protein into β-sheet-rich...
[会议论文] 作者：Chenyun Guo,Zhihua Wu,Haiping Zhang,Zhiliang Ji,Donghai Lin,
来源：中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 年份：2014
...
[会议论文] 作者：Jing HONG,Chenyun GUO,Donghai LIN,xiaojing HE,Aihua LIANG,
来源：第二届全国“跨学科蛋白质研究”学术讨论会 年份：2008
...
[会议论文] 作者：Fang Zhang,Jiafu Liu,Hongchang Gao,Chenyun Guo,Donghai Lin,
来源：第一届海峡两岸磁共振学术会议 年份：2007
Lipocalins play important roles in regulation of immunological and developmental processes.As a family of extracellular proteins that share a common fold fe...
[会议论文] 作者：Donghai LIN,Yu PENG,Jiafu LIU,Xu ZHANG,Chenyun GUO,
来源：BCEIA2011第十四届北京分析测试学术报告会 年份：2011
...
[会议论文] 作者：Jing HONG,Chenyun GUO,xiaojing HE,Aihua LIANG,Donghai LIN,
来源：第二届全国“跨学科蛋白质研究”学术讨论会 年份：2008
...
,Expression and purification of cysteine mutation isoforms of rat lipocalin-type prostaglandin D syn
[期刊论文] 作者：Jiafu Liu,Kejiang Lin,Chenyun Guo,Hongchang Gao,Yihe Yao,Donghai Lin,
来源：生物化学与生物物理学报(英文版) 年份：2008
Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is the only member of the lipocalin superfamily that displays enzymatic activity. It binds lipophilic liga...
[会议论文] 作者：Chenyun Guo,Zhihua Wu,Cuiping Fu,Lu Ruan,Lina Shi,Donghai Lin,
来源：中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 年份：2014
Raft kinase inhibitor protein (RKIP) directly interacts with Rafl kinase, thereby regulatingthe Rafl/MEK/ERK pathway which is vital for cell growth and differentiation.However, little is known about t...
,Distinct effects of mutations on biophysical properties of human prion protein monomers and oligome
[期刊论文] 作者：Yuanhui Yu,Ziyao Yu,Zhen Zheng,Huilin Wang,Xueji Wu,Chenyun Guo,Donghai Lin,
来源：生物化学与生物物理学报（英文版） 年份：2016
...
[期刊论文] 作者：Kejiang Lin,Ziyao Yu,Yuanhui Yu,Xinli Liao,Pei Huang,Chenyun Guo,Donghai Lin,
来源：生物化学与生物物理学报（英文版） 年份：2015
...
,Recombinant expression, biophysical and functional characterization of ClpS from Mycobacterium tube
[期刊论文] 作者：Chenyun Guo,Yihang Xiao,Fangkai Bi,Weiliang Lin,Huilin Wang,Hongwei Yao,Donghai Lin,
来源：生物化学与生物物理学报（英文版） 年份：2019
Intracellular proteolysis is attracting more and more attention for its unique and important character in Mycobacterium tuberculosis (Mt).The ClpS protein from...
,Anti-leprosy drug Clofazimine binds to human Raf1 kinase inhibitory protein and enhances ERK phosph
[期刊论文] 作者：Chenyun Guo,Ting Chang,Tao Sun,Zhihua Wu,Yazhuang Dai,Hongwei Yao,Donghai Lin,
来源：生物化学与生物物理学报（英文版） 年份：2018
Human Raf1 kinase inhibitory protein (hRKIP) is an important modulator of the Ras/Raf1/MEK/ERK signaling pathway.Here,we demonstrated that anti-leprosy drug Clo...
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