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Modification,Biological Evaluation and 3D QSAR Studies of Novel 2-(1,3-Diaryl-4,5-Dihydro-1 H-Pyrazo
[会议论文] 作者:Yu-Shun Yang,Fei Zhang,Dan-Jie Tang,Yong-Hua Yang,Hai-Liang Zhu,
来源:第八届国际分子模拟与信息技术应用学术会议 年份:2016
A series of novel 2-(1,3-diaryl-4,5-dihydro-1H-pyrazol-5-yl)phenol derivatives(C1-C24)have been synthesized.The B-Raf inhibitory activity and anti-proliferation activity of these compounds have been t...
Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetasedesign, synthe
[会议论文] 作者:Long-Wang Chen,Peng-Fei Wang,Dan-Jie Tang,Xiang-Xiang Tao,Ruo-Jun Man,Han-Yue Qiu,Zhong-Chang Wang,Chen,
来源:第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018) 年份:2018
As an important enzyme in bacterial protein biosynthesis,tyrosyl-tRNA synthetase(TyrRS)has been an absorbing therapeutic target for exploring novel antibact...
Synthesis and Biological Evaluation of 1-Methyl-1H-indole-Pyrazoline Hybrids as Potential Tubulin Po
[会议论文] 作者:Ya-Liang Zhang,Ya-Juan Qin,Dan-Jie Tang,Meng-Ru Yang,Bo-Yan Li,Yan-Ting Wang,Hong-Yu Cai,Bao-Zhong Wang,
来源:第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018) 年份:2018
A series of 1-methyl-1H-indole–pyrazoline hybrids were designed,synthesized,and biologically evaluated as potential tubulin polymerization inhibitors.Among the...
Synthesis and Biological Evaluation of 1-Methyl-1H-indole-Pyrazoline Hybrids as Potential Tubulin Po
[会议论文] 作者:Ya-Liang Zhang,Ya-Juan Qin,Dan-Jie Tang,Meng-Ru Yang,Bo-Yan Li,Yan-Ting Wang,Hong-Yu Cai,Bao-Zhong Wang,
来源:第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018) 年份:2018
...
Synthesis and Biological Evaluation of 1-Methyl-1H-indole-Pyrazoline Hybrids as Potential Tubulin Po
[会议论文] 作者:Ya-Liang Zhang,Ya-Juan Qin,Dan-Jie Tang,Meng-Ru Yang,Bo-Yan Li,Yan-Ting Wang,Yan-Ting Wang,Bao-Zhong,
来源:第八届国际分子模拟与信息技术应用学术会议 年份:2016
A series of 1-methyl-1H-indole-pyrazoline hybrids were designed,synthesized,and biologically evaluated as potential tubulin polymerization inhibitors.Among them,compound e19 [5-(5-bromo-1-methyl-1H-in...
Synthesis and biological evaluation of novel indole derivatives containing sulfonamide scaffold as p
[会议论文] 作者:Ruo-Jun Man,Dan-Jie Tang,Xiao-Yuan Lu,Yong-Tao Duan,Xiang-Xiang Tao,Meng-Ru Yang,Le-Le Wang,Bao-Zhong,
来源:第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018) 年份:2018
Microtubule-targeted drugs play a critical role in various types of cancer therapy worldwide.In our study,a series of novel indole derivatives containing su...
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