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[期刊论文] 作者：Shusheng Geng,Jiannan Feng,Yan,
来源：中国免疫学杂志 年份：2007
In this study, we discussed the necessity of human IgG1 Cγ1 domain for recombinant antibody using computeraided homology modeling method and experimental studi...
The comparison of BLyS-binding peptides from phage display library and computer-aided design on BLyS
[会议论文] 作者：Yacong Zhao,Xiafei Hao,Jiannan Feng,Beifen Shen,Jing Wei,Jian Sun,
来源：第八届国际分子模拟与信息技术应用学术会议 年份：2016
BLyS antagonists have become the therapeutic reagents in the treatment of autoimmune disorders.BLyS binding peptides and their Fc fusion proteins may be altemative BLyS antagonists in Such application...
[会议论文] 作者：Shusheng Geng,Shusheng Geng,Weisong Qin,Ming Lv,Yan Li,Jiannan Feng,Beifen Shen,
来源：第八届国际分子模拟与信息技术应用学术会议 年份：2016
The introduction of INF inhibitors has revolutionized the treatment of some chronic inflammatory diseases,e.g.,rheumatoid arthritis and Crohns disease.However,immunogenics ty is one of the important m...
In vitro molecular evolution of anti-Her2 antibody MILS using an computer-aided epitope-specific syn
[会议论文] 作者：Chunxia Qiao,Ming Lv,Zhou Lin,Longlong Luo,Jing Geng,Yan Li,Jiannan Feng,Beifen Shen,
来源：第六届全国生物治疗学术大会 年份：2012
Increased affinities mainly equals to improved biological efficacy in many cases.By now display methods including phage library are widely exploited to obtain higher affinity antibodies.Traditional li...
[会议论文] 作者：Jianing Wang,Jiannan Feng,Ming Shi,Lu Qian,Liyong Chen,Ming Yu,Ruonan Xu,Beifen Shen,Ning Guo,
来源：第一届世界华人免疫学大会(International Conference on Immunology 2007) 年份：2007
...
Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-ce
[会议论文] 作者：Jian Cui,Qingyang Wang,Jing Wang,Ming Lv,Ning Zhu,Yan Li,Jiannan Feng,Beifen Shen,Jiyan Zhang,
来源：2010中国青年遗传学家论坛 年份：2010
Hyperactivation of c-Jun NH2-terminal protein kinase (JNK) has been found in various malignant lymphocytes and inhibition of JNK activity leads to cell cycl...
Affinity maturation of antiHER2 monoclonal antibody MIL5 using an epitope-specific synthetic phage l
[会议论文] 作者：Chunxia Qiao,Ming Lv,Xinying Li,Jing Geng,Yan Li,Jiyan Zhang,Zhou Lin,Jiannan Feng,Beifen Shen,
来源：第七届国际分子模拟与信息技术应用学术会议 年份：2014
Increased affinities mainly equal to improved biological efficacy in many cases.By now, display methods including phage library are widely exploited to obtain higher affinity antibodies.Traditional li...
[期刊论文] 作者：Hao Liu,Chunxia Qiao,Naijing Hu,Zhihong Wang,Jing Wang,Jiannan Feng,Beifen Shen,Yuanfang Ma,Longlong,
来源：工程（英文） 年份：2021
Immunotherapy with anti-programmed cell death protein-1(PD-1)/programmed cell death ligand-1(PD-L1)monoclonal antibodies has become routine in the treatment of many kinds of human cancers,such as lung cancer,intestinal cancer,and melanoma.T......
[期刊论文] 作者：Guang Yang,Yaping Gao,Jiannan Feng,Yong Huang,Shaohua Li,Yu Liu,Chuan Liu,Ming Fan,Beifen Shen,Ningsheng,
来源：生物化学与生物物理学报（英文版） 年份：2008
In Staphylococcus aureus, the target of RNAⅢ activating protein (TRAP) is a membrane-associated protein whose Cterminus can be used as a vaccine to provide pro...
Complement activation promotes colitis-associated carcinogenesis through activating intestinal IL-1β
[会议论文] 作者：Guojiang Chen,Chang Ning,Yuanyuan Li,Gencheng Han,Renxi Wang,He Xiao,Chunmei Hou,Beifen Shen,Jiannan Feng,
来源：中国免疫学会第十届全国免疫学学术大会 年份：2015
Colitis-associated colorectal cancer (CAC) is the most serious complication of inflammatory bowel disease (IBD)....
Binding Activity Difference of Anti-CD20 scFv-Fc Fusion Protein Derived from Variable Domain Exchang
[期刊论文] 作者：Shusheng Geng,Jiannan Feng,Yan Li,Yingxun Sun,Xin Gu,Ying Huang,Yugang Wang,Xianjiang Kang,Hong Chang,
来源：中国免疫学杂志（英文版） 年份：2006
Two novel engineered antibody fragments binding to antigen CD20 were generated by fusing a murine IgM-type anti-CD20 single-chain Fv fragment (scFv) to the huma...
Complement activation promotes colitis-associated carcinogenesis through activating intestinal IL-1β
[会议论文] 作者：Renxi Wang,Yan Li,Guojiang Chen,He Xiao,Chunmei Hou,Beifen Shen,Gencheng Han,Jiannan Feng,Chang Ning,,
来源：中国免疫学会第十届全国免疫学学术大会 年份：2015
Colitis-associated colorectal cancer (CAC) is the most serious complication of inflammatory bowel disease (IBD)....
A Single Chain Antibody using LoxP511 as the Linker Enables Large-Content Phage Library Construction
[会议论文] 作者：Yan Zhang,Chunxia Qiao,Jiannan Feng,Wei Wang,Ming Lv,Zhou Lin,Jing Geng,Yali Li,Beifen Shen,Yuanfang,
来源：第七届国际分子模拟与信息技术应用学术会议 年份：2014
To obtain natural or "me-better" antibodies (e.g., affinity-maturated antibodies), phage display libraries are widely used.However, the likelihood of obtaining satisfactory antibodies depends on the l...
[会议论文] 作者：Jing Yang,Ming Lv,Jiannan Feng,Qun Wang,Chunxia Qiao,Zhou Lin,Xinying Li,Yifei Huang,Tingting Zhou,Yan,
来源：第七届国际分子模拟与信息技术应用学术会议 年份：2014
Angiogenesis is crucial for tumor development, growth and metastasis.Vascular endothelial growth factor (VEGF) has been implicated in promoting sol id tumor growth and metastasis via stimulating tumor...
[会议论文] 作者：Longlong Luo,Chunxia Qiao,Jiannan Feng,Qun Luo,Leiming Guo,Ming Lv,Zhou Lin,Jing Geng,Xinying Li,Yan,
来源：第七届国际分子模拟与信息技术应用学术会议 年份：2014
Ricin is a highly lethal toxin.Anti-ricin chineric monoclonal antibody (mAb) C4Cl3 was prepared in our lab;however, its binding affinity was moch weaker than that of the parent antibody 4C13.In this s...
[期刊论文] 作者：Ming Lv,Xinying Li,Xiaoling Lang,Shouqin Lv,Mian Long,Yan Li,Shusheng Geng,Zhou Lin,Beifen Shen,Jiannan Feng,
来源：工程（英文） 年份：2021
Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or......
Characterization of a Novel Anti-DR5 Monoclonal Antibody WD1 with the Potential to Induce Tumor Cell
[期刊论文] 作者：Jing Wang,Zhou Lin,Chunxia Qiao,Ming Lv,Ming Yu,He Xiao,Qingyang Wang,Liyan Wang,Jiannan Feng,Beifen,
来源：中国免疫学杂志（英文版） 年份：2008
...
Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-acti
[会议论文] 作者：Yuanyuan Guo,Yuanfang Ma,Beifen Shen,Jiyan Zhang,Wendie Wang,Jing Wang,Jiannan Feng,Qingyang Wang,Jianfeng,
来源：第八届全国免疫学学术大会 年份：2012
...
T cell Ig mucin-3 promotes homeostasis of sepsis by negatively regulating the Toll-like receptor res
[会议论文] 作者：Xiaomei Yang,Jiannan Feng,Yuanfang Ma,Beifen Shen,Yan Li,Gencheng Han,Xingwei Jiang,Guojiang Chen,Shaoxia,
来源：第八届全国免疫学学术大会 年份：2012
...
Disruption of TAB1/p38α Interaction Using a Cell-permeable Peptide Limits Myocardial Ischemia/Reperf
[会议论文] 作者：Qingyang Wang,Junxia Cao,Xinying Li,Hui Peng,Yan Li,Beifen Shen,Jiyan Zhang,Jiannan Feng,Jing Wang,Xueying,
来源：第七届国际分子模拟与信息技术应用学术会议 年份：2014
Targeting the adaptor protein (transforming growth factor-β (TGF-β)-activated protein kinase 1 (TAK1)-binding protein 1) (TAB1)-mediated non-canonical activation of p38α to limit ischemia/reperfusion...
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