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,Induction of leukemia cell apoptosis by cheliensisin A involves down-regulation of Bcl-2 expression
[期刊论文] 作者：Li ZHONG,Chao-ming LI,Xiao-jiang HAO,Li-guang LOU,
来源：中国药理学报（英文版） 年份：2005
Aim: To investigate the apoptosis-inducing effect of cheliensisin A (GC-51), a novel styryl-lactone isolated from Goniothalamus cheliensis, on human promyelocyt...
DCZ5248,a novel dual inhibitor of Hsp90 and autophagy,exerts antitumor activity against colon cancer
[期刊论文] 作者：Xiang-ling Chen,Peng Liu,Wei-liang Zhu,Li-guang Lou,
来源：中国药理学报（英文版） 年份：2021
Hsp90 is a potential therapeutic target for tumor,as it maintains the stability of a variety of proteins related to tumor development and progression.Autophagy...
,Curcumin derivative C817 inhibits proliferation of imatinib-resistant chronic myeloid leukemia cell
[期刊论文] 作者：Li-xian WU,Ying WU,Rui-jia CHEN,Yang LIU,Li-sen HUANG,Li-guang LOU,Zhi-hong ZHENG,
来源：中国药理学报（英文版） 年份：2014
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,SHR-A1403, a novel c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-o
[期刊论文] 作者：Chang-yong Yang,Lei Wang,Xing Sun,Mi Tang,Hai-tian Quan,Lian-shan Zhang,Li-guang Lou,Shao-hua Gou,
来源：中国药理学报（英文版） 年份：2019
Emerging evidence demonstrates that a c-Met antibody-drug conjugate (ADC) has superior efficacy and safety profiles compared with those of currently available s...
,Aberrant modulation of ribosomal protein S6 phosphorylation confers acquired resistance to MAPK pat
[期刊论文] 作者：Ming-zhao Gao,Hong-bin Wang,Xiang-ling Chen,Wen-ting Cao,Li Fu,Yun Li,Hai-tian Quan,Cheng-ying Xie,Li-guang Lou,
来源：中国药理学报（英文版） 年份：2019
BRAF and MEK inhibitors have shown remarkable clinical efficacy in BRAF-mutant melanoma;however,most patients develop resistance,which limits the clinical benef...
,Pharmacokinetics and disposition of anlotinib,an oral tyrosine kinase inhibitor, in experimental an
[期刊论文] 作者：,Fei-fei DU,Su-ping ZHANG,Chengying XIE,Na-ting ZHANG,Olajide E OLALEYE,Feng-qing WANG,Fang XU,Li-guang LOU,
来源：中国药理学报（英文版） 年份：2018
Anlotinib is a new oral tyrosine kinase inhibitor; this study was designed to characterize its pharmacokinetics and disposition. Anlotinib was evaluated in rats...
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