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Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for A
[期刊论文] 作者:Qin NIE,Xiao-guang DU,Mei-yu GENG,
来源:中国药理学报(英文版) 年份:2011
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,Oligomannurarate sulfate inhibits CXCL12/SDF-1-mediated proliferation and invasion of human tumor c
[期刊论文] 作者:Wei-wei WEN,Shao XIE,Xian-liang XIN,Mei-yu GENG,Jian DING,Yi CHEN,
来源:中国药理学报(英文版) 年份:2013
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,Evaluation of in vitro and in vivo activity of a multityrosine kinase inhibitor, AL3810, against hu
[期刊论文] 作者:Qin XIE,Hui CHEN,Jing AI,Ying-lei GAO,Mei-yu GENG,Jian DING,Yi CHEN,
来源:中国药理学报(英文版) 年份:2017
Thyroid cancer is the most common type of endocrine neoplasia.Despite recent breakthroughs in treatment of the disease,the treatment of advanced,progressive thy...
Effects of dermatan sulfate derivatives on platelet surface P-selectin expression and protein C acti
[期刊论文] 作者:Sheng-Li Ji,Hai-Yan Du,Yan-Qing Chi,Hui-Fei Cui,Ji-Chao Cao,Mei-Yu Geng,Hua-Shi Guan,
来源:世界胃肠病学杂志(英文版) 年份:2004
AIM: To investigate the effect of dermatan sulfate (DS)derivatives on platelet surface P-selectin expression and blood activated protein C (APC) activity in pat...
Inhibitory effect of heparin-derived oligosaccharides on secretion of interleukin-4 and interleukin-
[期刊论文] 作者:Sheng-Li Ji,Hui-Fei Cui,Feng SHI,Yan-Qing Chi,Ji-Chao Cao,Mei-Yu Geng,Hua-Shi Guan,
来源:世界胃肠病学杂志(英文版) 年份:2004
AIM: To investigate the inhibitory effect of heparin-derived oligosaccharides (Oligs) on secretion of interleukin-4 (IL-4)and interleukin-5 (IL-5) from human pe...
[期刊论文] 作者:Jin QIAN,Cai-hua ZHU,Shuai TANG,Ai-jun SHEN,Jing AI,Jing LI,Mei-yu GENG,Jian DING,
来源:中国药理学报(英文版) 年份:2009
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Sulfated polymannuroguluronate inhibits Tat-induced SLK cell adhesion via a novel binding site, a KK
[期刊论文] 作者:Yan-lin WU,Jing AI,Jing-ming ZHAO,Bing XIONG,Xiao-jie XIN,Mei-yu GENG,Xian-liang XIN,Han-dong JIANG,
来源:中国药理学报(英文版) 年份:2011
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[期刊论文] 作者:Jing ZHANG,Yi CHEN,Xian-liang XIN,Qiu-ning LI,Ming LI,U-ping LIN,Mei-yu GENG,Jian DING,
来源:中国药理学报(英文版) 年份:2010
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,GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-in
[期刊论文] 作者:Hua XIE,Yu-xin QIN,Yun-long ZHOU,Lin-jiang TONG,Li-ping LIN,Mei-yu GENG,Wen-hu DUAN,Jian DING,
来源:中国药理学报(英文版) 年份:2009
Aim: Gambogic acid (GA) is the major active ingredient of gamboge, which is secreted from a Chinese traditional medicine, Garcinia hanburyi, which possesses pot...
[期刊论文] 作者:Yue-hong Chen,Hao Lv,Ning Shen,Xiao-min Wang,Shuai Tang,Bing Xiong,Jian Ding,Mei-yu Geng,Min Huang,
来源:中国药理学报(英文版) 年份:2020
KRAS is one of the most important proto-oncogenes.Its mutations occur in almost all tumor types,and KRAS mutant cancer is still lack of effective therapy.Prenyl...
,Marine-derived oligosaccharide sulfate (JG3) suppresses heparanase-driven cell adhesion events in h
[期刊论文] 作者:Qiu-ning LI,Hai-ying LIU,Xian-liang XIN,Qiu-ming PAN,Lu WANG,ling ZHANG,Qin CHEN,Mei-yu GENG,Jian DING,
来源:中国药理学报(英文版) 年份:2009
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[期刊论文] 作者:Rong-rui WEI,Dan-ni SUN,Hong YANG,Juan YAN,Xiong ZHANG,Xing-ling ZHENG,Xu-hong FU,Mei-yu GENG,Xun HUANG,
来源:中国药理学报(英文版) 年份:2018
Aggregated metastatic cancer cells,referred to as circulating tumor cell (CTC) clusters,are present in the blood of cancer patients and contribute to cancer met...
[期刊论文] 作者:Tian Fang,Dan-dan Liu,He-ming Ning,Dan Liu,Jing-ya Sun,Xiao-jing Huang,Yu Dong,Mei-yu Geng,Shi-feng Yun,
来源:中国药理学报(英文版) 年份:2018
Modified citrus pectin (MCP) is a carbohydrate enriched complex,which has been implicated in cancer treatment and prevention.However,the effects of MCP on urina...
SAF-189s,a potent new-generation ROS1 inhibitor,is active against crizotinib-resistant ROS1 mutant-d
[期刊论文] 作者:Yin-chun Ji,De-qiao Sun,Xia Peng,Ying-lei Gao,Yan-fen Fang,Xing-dong Zhao,Wei-bo Wang,Jian Ding,Mei-yu Geng,
来源:中国药理学报(英文版) 年份:2021
The ROS1 fusion kinase is an attractive antitumor target.Though with significant clinical efficacy,the well-known first-generation ROS1 inhibitor(ROS1 i)crizotinib inevitably developed acquired resistance due to secondary point mutations in......
,CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in
[期刊论文] 作者:Yang,Xiao-wei Xu,Zong-long Hu,Juan Yan,Xing-ling Zheng,Rong-rui Wei,Zhu-qing Zhang,Shi-rui Tang,Mei-yu Geng,
来源:中国药理学报(英文版) 年份:2019
Pancreatic adenocarcinoma is a highly malignant cancer that often involves a deregulation of c-Myc.It has been shown that c-Myc plays a pivotal role in the regu...
,Marine-derived chromopeptide A, a novel class Ⅰ HDAC inhibitor, suppresses human prostate cancer ce
[期刊论文] 作者:Hong-chun LIU,Min-min ZHANG,Yu-Chih LIU,Chen-hua ZHANG,Yi SU,Yan-yan SHEN,Yue-wei GUO,Ai-jun SHEN,Mei-yu GENG,
来源:中国药理学报(英文版) 年份:2017
Histone deacetylases (HDACs),especially HDAC1,2,3 and 4,are abundantly expressed and over-activated in prostate cancer that is correlated with the poor prognosi...
,Establishment of platform for screening insulin-like growth factor-1 receptor inhibitors and evalua
[期刊论文] 作者:,Hua XIE,Ting PENG,Xiao-feng LIU,Xian-liang XIN,Xun HUANG,Si-meng CHEN,Hong-yan LIU,Hong-lin LI,Mei-yu GENG,
来源:中国药理学报(英文版) 年份:2011
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SAF-248,a novel PI3Kδ-selective inhibitor,potently suppresses the growth of diffuse large B-cell lym
[期刊论文] 作者:Xing-dong Zhao,Yi-ming Sun,Dong-ze Lin,Yi Chen,Yu-xiang Wang,Zu-wen Zhou,Yan-xin Liu,Li-hua Jiang,Mei-yu Geng,
来源:中国药理学报(英文版) 年份:2022
PI3Kδ is expressed predominately in leukocytes and overexpressed in B-cell-related malignances.PI3Kδ has been validated as a promising target for cancer therapy,and specific PI3Kδ inhibitors were approved for clinical practice.However,th......
[期刊论文] 作者:Lu,Lin-Jiang Tong,Yan Li,Tao Zhang,Qiu-Ju Xun,Fang Feng,Yu-Zhe Chen,Yi Su,Yan-Yan Shen,Yi Chen,Mei-Yu Geng,
来源:中国药理学报(英文版) 年份:2018
Colony-stimulating factor 1 receptor (CSF1R) plays a critical role in promoting tumor progression in various types of tumors.Here,we identified D2923 as a novel...
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumat
[期刊论文] 作者:Liu,Xiao-qian Yang,Feng-hua Zhu,Yue-teng Huang,Shi-qi Cao,Fang-ming Yang,Zi-lan Song,Jian Ding,Mei-yu Geng,
来源:中国药理学报(英文版) 年份:2021
Rheumatoid arthritis (RA) is characterized by joint leukocyte infiltration,synovial inflammation and bone damage result from osteoclastogenesis.Bruton\'s tyrosine kinase (BTK) is a key regulator of B cell receptor (BCR) and Fc gamma recepto......
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