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Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced par
[期刊论文] 作者：Qian-hang SHAO,Yu-he YUAN,Nai-hong CHEN,,
来源：中国药理学与毒理学杂志 年份：2017
OBJECTIVE To evaluate these activities of Rg1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)/probenecid(MPTP/p)-induced PD mouse model for the first...
[期刊论文] 作者：Xiao-ling ZHANG,Yu-he YUAN,Nai-hong CHEN,,
来源：中国药理学与毒理学杂志 年份：2017
20C,a bibenzyl compound isolated from Gastrodia elata,possesses antioxidative properties in PC12 cells,but its in-depth molecular mechanisms against rotenone-in...
[期刊论文] 作者：Lu WEN,Yu-he YUAN,Nai-hong CHEN,,
来源：中国药理学与毒理学杂志 年份：2017
OBJECTIVE(1) To estimate the value of the subacute MPTP mouse model in aspects of behavioral performance,biochemical changes and pathological abnormalities.(2)...
[会议论文] 作者：Jia-qing YAN,Yu-he YUAN,Nai-hong CHEN,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
...
[会议论文] 作者：Jiao CHEN,Shi-feng CHU,Nai-hong CHEN,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
Aim: To explore the effect of adrenalectomy (ADX) on chronic stress-induced depression.Methods: The investigation activity and emotional changes was recorded in...
Regulation of mTORC1 signaling network underlying the pathophysiology and treatment of depression ne
[会议论文] 作者：Ting ZENG,Zhen-zhen WANG,Nai-hong CHEN,
来源：中国药理学会北美分会药理学学术大会 年份：2017
Depression is a devastating mental disorder and major depressive disorder afflictsabout 16% of the world population at some point in their lives....
Regulation of mTORC1 signaling network underlying the pathophysiology and treatment of depression: n
[会议论文] 作者：Ting ZENG,Nai-hong CHEN,Zhen-zhen WANG,
来源：中国药理学会北美分会药理学学术大会 年份：2017
Depression is a devastating mental disorder and major depressive disorder afflictsabout 16% of the world population at some point in their lives....
Protective effects of polygalasaponin F on PC12 cells injuried by serum deprivation, oxidative stres
[会议论文] 作者：Rui-li Shi,Jin-feng Hu,Nai-hong Chen,
来源：International Conference for Physiological Sciences 2012(201 年份：2012
Aim To study the effects of Polygalasaponin F (PGSF) on PC12 cells.Methods The viability of cells was determined by MTT assay.Cell apoptosis was assessed by propidium iodide/Hoechst 33258 staining and...
Detection of simultaneous glutamate and GABA release from primary cortical neuronal cultures by RT-H
[会议论文] 作者：Yun ZHANG,Zhi-Jun LIU,Nai-Hong CHEN,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
Objective Synaptic transmission is conducted by neurotransmitters released from nerve terminals.Neurotrans-mitter release is regulated both positively and negatively by multiple mechanisms and its reg...
[期刊论文] 作者：Vivian SZETO,Nai-hong CHEN,Hong-shuo SUN,Zhong-ping FENG,
来源：中国药理学报（英文版） 年份：2018
ATP-sensitive potassium (KATP) channels are ubiquitously expressed on the plasma membrane of cells in multiple organs, including the heart, pancreas and brain....
Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative dis
[期刊论文] 作者：Si-yu Ren,Zhen-zhen Wang,Yi Zhang,Nai-hong Chen,
来源：中国药理学报（英文版） 年份：2020
The endocannabinoid system (ECS) has received extensive attention for its neuroprotective effect on the brain.This system comprises endocannabinoids,endocannabi...
[会议论文] 作者：Qian REN,Cong-yuan XIA,Zhen-zhen WANG,Nai-hong CHEN,
来源：中国药理学会北美分会药理学学术大会 年份：2017
The present study aimed to observe the protective effect of ginsenoside Rg1 on corticosterone(CORT)-induced injury in primary astrocytes and its underlying...
[会议论文] 作者：Qian REN,Zhen-zhen WANG,Cong-yuan XIA,Nai-hong CHEN,
来源：中国药理学会北美分会药理学学术大会 年份：2017
The present study aimed to observe the protective effect of ginsenoside Rg1 on corticosterone(CORT)-induced injury in primary astrocytes and its underlying...
[会议论文] 作者：Jiao Chen,Zhen-zhen Wang,Wei Zuo,Nai-hong Chen,
来源：第五届中国药理学会补益药药理专业委员会学术研讨会 年份：2015
Depression is a leading cause of disability worldwide.However the biological and molecular mechanisms underlying this disorder remain to be unknown.Stress is a disposing factor in the development of d...
[会议论文] 作者：Jian-ping LI,Shi-feng CHU,Yan GAO,Nai-hong CHEN,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
Aim: The aim of the the present study was to investigate the effects of FLC, a plantderived compound, on the acute liver injury in mice induced by LPS/D-GalN.Methods: A mixture of LPS/D-GalN was admin...
Facilitating synaptic transmission of (-)clausenamide in CA1 region of hippocampal slices by activat
[会议论文] 作者：Jin-Feng HU,Na Ning,Yu-He YUAN,Jun-Tian ZHANG,Nai-Hong CHEN,
来源：中国神经科学学会第九届全国学术会议暨第五届会员代表大会 年份：2011
Objective Effect of (-)clausenamide on potentiating field excitatory postsynaptic potential (f-EPSP) in CA1 region of rats hippocampal slice and its related mechanism were investigated in the paper.Me...
[期刊论文] 作者：Hong-yun Wang,Jun-rui Ye,Li-yuan Cui,Shi-feng Chu,Nai-hong Chen,
来源：中国药理学报（英文版） 年份：2022
Recent evidence shows that when ischemic stroke(IS)occurs,the BBB would be destructed,thereby promoting the immune cells to migrate into the brain,suggesting that the immune responses can play a vital role in the pathology of IS.As an essen......
[期刊论文] 作者：Chang-suo LIU,Yong CHENG,Jin-feng HU,Wei ZHANG,Nai-hong CHEN,Jun-tian ZHANG,
来源：中国药理学报（英文版） 年份：2006
Aim: To investigate and compare the antioxidant activities of salvianolic acid B (SalB) and Ginkgo biloba extract (EGb 761) in aqueous solution, rat microsomes...
,Ginsenoside Rg1 activated CaMKIIα mediated extracellular signal-regulat-ed kinase/mitogen activated
[期刊论文] 作者：Jin-feng HU,Wei XUE,Na NING,Yu-he YUAN,Jun-tian ZHANG,Nai-hong CHEN,
来源：中国药理学报（英文版） 年份：2008
Aim:We carried out this study to investigate the effect of ginsenoside Rg1 on the extracellular signal-regulated kinase/mitogen activated protein kinase (ERK/ M...
[期刊论文] 作者：Na NING,Jin-feng HU,Yu-he YUAN,Xin-yuan ZHANG,Jun-gui DAI,Nai-hong CHEN,
来源：中国药理学报（英文版） 年份：2012
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