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[期刊论文] 作者:Robert B. Raffa, 来源:药理与制药(英文) 年份:2012
Several preclinical and clinical studies suggested that tramadol has a multi-mechanistic analgesic action. Upon in vitro evaluation, tramadol parent drug was de...
[期刊论文] 作者:Robert B. Raffa,Gerwin Westfie, 来源:药理与制药(英文) 年份:2019
Insomnia and related sleep disorders (somnipathies) affect a large segment of the population, and result in a significant negative impact on quality of life and...
[期刊论文] 作者:Wanhui Sheng,Robert B. Raffa, 来源:药理与制药(英文) 年份:2018
Planarians have mammalian-like neurotransmitter systems and have been established as a novel in vivo model for neuropharmacology. In previous research, planaria...
[期刊论文] 作者:Robert B. Raffa,Christopher S., 来源:药理与制药(英文) 年份:2012
Based on previous work, it has been hypothesized that the energetics of ultraviolet (UV) light disrupts effects induced by receptor-binding ligands. If this hyp...
[期刊论文] 作者:Robert B. Raffa,Christopher S., 来源:药理与制药(英文) 年份:2012
Excess weight is a major risk factor for type-2 diabetes, cardiovascular disease, and other comorbidities. Animal models of feeding provide insight into the pro...
[期刊论文] 作者:Robert B. Raffa,Joseph V. Perg, 来源:药理与制药(英文) 年份:2019
Lucemyra? (lofexidine hydrochloride) has recently been approved by the US FDA for the mitigation of withdrawal symptoms to facilitate abrupt discontinuation of...
[期刊论文] 作者:Robert B. Raffa,Joseph V. Perg, 来源:药理与制药(英文) 年份:2019
Treatment of health problems that accompany aging often includes pharmacotherapy. It is thus common for older adults—and, increasingly, younger adults—to be o...
[期刊论文] 作者:Robert B. Raffa,Joseph V. Perg, 来源:药理与制药(英文) 年份:2019
Benzodiazepines and related benzodiazepine-receptor agonists such as the pyrazolopyrimidinezalepl -on;?the imidazopyridine zolpidem;and the cyclopyrroloneszopic...
[期刊论文] 作者:Robert B. Raffa,Joseph V. Perg, 来源:药理与制药(英文) 年份:2018
The most frequent adverse event in the healthcare delivery system is acquisition of an infection within a healthcare facility. Since infection control measures...
[期刊论文] 作者:Robert B. Raffa,Joseph V. Perg, 来源:药理与制药(英文) 年份:2019
General anesthetics constitute some of the most important and widely-used therapeutic drugs in the pharmacotherapeutic armamentarium. They are routinely used ef...
[期刊论文] 作者:Robert B. Raffa,Deborah A. Gal, 来源:药理与制药(英文) 年份:2012
Agricultural, pharmaceutical, and other biologically active substances are emptied or leach into waterways and groundwater, where they can dose-relatedly cause...
[期刊论文] 作者:Robert B. Raffa,Joseph V. Perg, 来源:药理与制药(英文) 年份:2020
Many therapeutic drugs are racemates;i.e. they are chiral molecules consisting of “left”- and “right-handed” enantiomers (stereoisomers that are mirror imag...
[期刊论文] 作者:Robert B. Raffa,Frank Breve,Ro, 来源:药理与制药(英文) 年份:2012
Falls represent a significant contribution to the morbidity and mortality of the elderly population. Because vitamin D is important in bone physiology, the use...
[期刊论文] 作者:Robert B. Raffa,Joseph V. Perg, 来源:药理与制药(英文) 年份:2018
The first “deuterated” drug has recently been approved by the U.S. FDA (Food & Drug Administration). A “deuterated” drug is a drug in which the hydrogen ato...
[期刊论文] 作者:Robert B. Raffa,Joseph V. Perg, 来源:药理与制药(英文) 年份:2018
Compliance to hand-hygiene guidelines in healthcare facilities remains disappointingly low for a variety of human-factors (HF) reasons. A device HF-engineered f...
[期刊论文] 作者:Robert B. Raffa,Joseph V. Perg, 来源:药理与制药(英文) 年份:2018
A healthcare-associated infection (defined as an infection acquired within a healthcare facility), such as due to transmission via medical equipment or by healt...
[期刊论文] 作者:Robert B. Raffa,Jeff Danah,Chr, 来源:帕金森(英文) 年份:2013
We previously created and investigated a planarian model for the study of drug action, abuse, physical dependence, receptor affinity, the toxicity of heavy meta...
[期刊论文] 作者:Robert B. Raffa,Sumira Shah,Ch, 来源:行为与脑科学期刊(英文) 年份:2013
Meth- and other amphetamines currently present major drug-abuse concerns. However, the demonstration and study of abuse-related behaviors expressed in animal mo...
[期刊论文] 作者:Pergolizzi,Alexander Kraus,Robert B. Raffa, 来源:生物科学与医学(英文) 年份:2021
There is accumulating evidence that the subfamily of large-conductance potassium (“big”, “BK”) channels are involved in diverse, and perhaps coordinated, pr...
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