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[期刊论文] 作者：Wei-Dong Le,
来源：中华医学杂志（英文版） 年份：2015
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[会议论文] 作者：Wei-Dong Le,
来源：首届昆明灵长类动物模型学术论坛 年份：2012
Parkinsons disease (PD) is one of the most prevalent neurodegenerative diseases characterized by the dopamine (DA) neuron degeneration in substantia nigra (SN)...
[会议论文] 作者：Wei-Dong Le,
来源：第二届灵长类动物模型学术论坛暨疾病动物模型学术及战略研讨会 年份：2013
Parkinsons disease(PD)is a progressive,neurodegenerative disorder of unknown etiology although a complex interaction between environmental and genetic facto...
[会议论文] 作者：Wei-Dong LE,
来源：中国神经科学学会第九届全国学术会议暨第五届会员代表大会 年份：2011
Autophagy is a lysosome degradation pathway that turns over cytoplasmic materials and helps the cell to maintain homeostasis.Usually, it is activated under conditions of nutrient deprivation in order...
[期刊论文] 作者：Pu PU Wei-Dong LE,
来源：神经科学通报：英文版 年份：2006
Parkinson disease(PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra. Although investigation in mammalian animal mod...
Progress in Diagnosing Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Epis
[期刊论文] 作者：Ying-Xin Wang,Wei-Dong Le,
来源：中华医学杂志（英文版） 年份：2015
Objective:Mitochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes (MELAS) is a progressive,multisystem affected mitochondrial disease ass...
[期刊论文] 作者：Wei-dong LE,Zheng-hong QIN,
来源：中国药理学报（英文版） 年份：2013
The word autophagy is derived from the Greek roots "auto"(self) and "phagy" (eating) and broadly refers to the cellular catabolic processes,in which cytoplasmic...
,Establishing a novel C.elegans model to investigate the role of autophagy in amyotrophic lateral sc
[期刊论文] 作者：Jia LI,Kai-xing HUANG,Wei-dong LE,
来源：中国药理学报（英文版） 年份：2013
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[期刊论文] 作者：Xiao-jie ZHANG,Sheng CHEN,Kai-xing HUANG,Wei-dong LE,
来源：中国药理学报（英文版） 年份：2013
...
[会议论文] 作者：Yun-Lan DU,De-Hua YANG,Liang LI,Wei-Dong LE,
来源：中国神经科学学会第九届全国学术会议暨第五届会员代表大会 年份：2011
The ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the two most important components of cellular mechanisms for protein degradation.In the present study we investigate...
[会议论文] 作者：Xiao-Jie ZHANG,Liang LI,Sheng CHEN,Wei-Dong LE,
来源：中国神经科学学会第九届全国学术会议暨第五届会员代表大会 年份：2011
Aberrant protein misfolding may contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS) but the detailed mechanisms are largely unknown.To investigate if there is any autophagic alterati...
[期刊论文] 作者：Xiao-Lan Xu,Song Li,Rong Zhang,Wei-Dong Le,
来源：中国神经再生研究（英文版） 年份：2022
Polysaccharides are macromolecular complexes that have various biological activities.In vivo and in vitro studies have shown that polysaccharides play neuroprotective roles through multiple mechanisms;consequently,they have potential in the......
[期刊论文] 作者：Yu-fei SHEN,Yu TANG,Xiao-jie ZHANG,Kai-xing HUANG,Wei-dong LE,
来源：中国药理学报（英文版） 年份：2013
...
[期刊论文] 作者：Feng Zhang,Ru-jia Zhong,Cheng Cheng,Song Li,Wei-dong Le,
来源：中国药理学报（英文版） 年份：2021
As the population ages,Alzheimer\'s disease (AD),the most common neurodegenerative disease in elderly people,will impose social and economic burdens to the world.Currently approved drugs for the treatment of AD including cholinesterase inhi......
[会议论文] 作者：Guang-Rui LUO,Yi CHEN,Xu-Ping LI,Ting-Xi LIU,Wei-Dong LE,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
Nurr1 has been recently found to be critical for the development and maintenance of mesencephalic dopamine (DA) neurons.To uncover the molecular mechanisms by which Nurr1 contributes to the developmen...
[会议论文] 作者：Liang LI,Xiao-Jie ZHANG,Peng XIE,De-Hua Yang,Guang-Rui LUO,Shen CHEN,Wei-Dong LE,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
Alzheimers disease (AD) is the most common neurodegenerative disorders in the central nervous system.Recently,environment factors have been considered a significant contributor for the development of...
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