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DCZ5248,a novel dual inhibitor of Hsp90 and autophagy,exerts antitumor activity against colon cancer
[期刊论文] 作者：Xiang-ling Chen,Peng Liu,Wei-liang Zhu,Li-guang Lou,
来源：中国药理学报（英文版） 年份：2021
Hsp90 is a potential therapeutic target for tumor,as it maintains the stability of a variety of proteins related to tumor development and progression.Autophagy...
,Computational insights into the G-protein-biased activation and inactivation mechanisms of the μ op
[期刊论文] 作者：Jian-xin CHENG,Tao CHENG,Wei-hua LI,Gui-xia LIU,Wei-liang ZHU,Yun TANG,
来源：中国药理学报（英文版） 年份：2018
The μ opioid receptor (OR),a member of the class A subfamily of G-protein coupled receptors (GPCRs),is a major target for the treatment of pain.G-protein biase...
,Computational insights into the subtype selectivity and message-address-efficacy mechanisms of opio
[期刊论文] 作者：Jian-xin CHENG,Tao CHENG,Wei-hua LI,Gui-xia LIU,Wei-liang ZHU,Yun TANG,
来源：中国药理学报（英文版） 年份：2018
In drug design and discovery,binding affinity and selectivity are two basic properties of a drug candidate.Opioid receptors (ORs) are the main targets of strong...
[期刊论文] 作者：Hai-yan CAI,Zhi-jian XU,Jie TANG,Ying SUN,Kai-xian CHEN,He-yao WANG,Wei-liang ZHU,
来源：中国药理学报（英文版） 年份：2012
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[期刊论文] 作者：Xue-lian ZHU,Hai-yan CAI,Zhi-jian XU,Yong WANG,He-yao WANG,Ao ZHANG,Wei-liang ZHU,
来源：中国药理学报（英文版） 年份：2011
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[期刊论文] 作者：Yan-qiong ZHANG,Song-song WANG,Wei-liang ZHU,Yan MA,Fang-bo ZHANG,Ri-xin LIANG,Hai-yu XU,
来源：中国药理学报（英文版） 年份：2015
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[期刊论文] 作者：Li-li LIU,Jing LU,Yin LU,Ming-yue ZHENG,Xiao-min LUO,Wei-liang ZHU,Hua-liang JIANG,
来源：中国药理学报（英文版） 年份：2014
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,Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor
[期刊论文] 作者：Kun ZOU,Zhao LI,Yong ZHANG,Hao-yue ZHANG,Bo LI,Wei-liang ZHU,Ji-ye SHI,
来源：中国药理学报（英文版） 年份：2017
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[会议论文] 作者：Hong LIU,Yong XU,De-iu YE,Jian LI,Min-yue ZHENG,Wei-liang ZHU,Hua-liang JIANG,
来源：2007年全国药物化学学术研讨会 年份：2007
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,Pharmacophore-based virtual screening versus docking-based virtual screening: a benchmark compariso
[期刊论文] 作者：Zhi CHEN,Hong-lin LI,Qi-jun ZHANG,Xiao-guang BAO,Kun-qian YU,Xiao-min LUO,Wei-liang ZHU,Hua-liang JIANG,
来源：中国药理学报（英文版） 年份：2009
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,Different structures of berberine and five other protoberberine alkaloids that affect P-glycoprotei
[期刊论文] 作者：Yi-ting Zhang,Yu-qi Yu,Xiao-xia Yan,Wen-jie Wang,Xiao-ting Tian,Le Wang,Wei-liang Zhu,Li-kun Gong,Guo-yu,
来源：中国药理学报（英文版） 年份：2019
Berberine,berberrubine,thalifendine,demethyleneberberine,jatrorrhizine,and columbamine are six natural protoberberine alkaloid (PA) compounds that display exten...
[期刊论文] 作者：WANG,Xiang WANG,Jian-ming ZHU,Bin-bin GUO,Zhuo YANG,Zhi-jian XU,Bo LI,He-yao WANG,Ling-hua MENG,Wei-liang ZHU,
来源：中国药理学报（英文版） 年份：2017
The mutation of B-RafV600E is widespread in a variety of human cancers.Its inhibitors vemurafenib and dabrafenib have been launched as drugs for treating unrese...
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