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[会议论文] 作者：Wenhui Shen,Dan Zhang,Yahong Wu,Xiuman Zhou,Wenshan Zhao,Yuanming Qi,Yanfeng Gao,
来源：2019中国肿瘤学大会 年份：2019
Objective Breast cancer is the most occurred cancer in women.Metastasis is the major cause of breast cancer-related death,and metastasis is a complex,multi-step biological process affected by the tumo...
A novel cyclic peptide targeting LAG-3 for cancer immunotherapy by activating antigen-specific CD8 +
[期刊论文] 作者：Wenjie Zhai,Xiuman Zhou,Hongfei Wang,Wanqiong Li,Guanyu Chen,Xinghua Sui,Guodong Li,Yuanming Qi,Yanfeng,
来源：药学学报（英文版） 年份：2020
PD-1 and CTLA-4 antibodies offer great hope for cancer immunotherapy.However,many patients are incapable of responding to PD-1 and CTLA-4 blockade and show low...
[期刊论文] 作者：Wenjie Zhai,Xiuman Zhou,Mingxia Zhai,Wanqiong Li,Yunhui Ran,Yixuan Sun,Jiangfeng Du,Wenshan Zhao,Lingxiao,
来源：中国科学：生命科学（英文版） 年份：2021
The interaction of PD-1/PD-L1 allows tumor cells to escape from immune surveillance.Clinical success of the antibody drugs has proven that blockade of PD-1/PD-L...
Tryptophan 2,3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cel
[期刊论文] 作者：Yumiao Zhao,Jiaxin Sun,Yin Li,Xiuman Zhou,Wenjie Zhai,Yahong Wu,Guanyu Chen,Shanshan Gou,Xinghua Sui,,
来源：药学学报（英文版） 年份：2021
Tryptophan 2,3-dioxygnease 2(TDO2)is specific for metabolizing tryptophan to kynurenine(KYN),which plays a critical role in mediating immune escape of cancer.Although accumulating evidence demonstrates that TDO2 overexpression is implicated......
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