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TRPC5 is necessary for neurotrophin-3 to induce intracellular calcium elevation and to inhibit dendr
[会议论文] 作者：Zhuohao HE,Yizheng WANG,
来源：中国神经科学学会第九届全国学术会议暨第五届会员代表大会 年份：2011
Neurotrophin-3 (NT-3), a member of neurotrophin family, exerts numerous functions in central nerves system regarding for its ability to induce intracellular calcium elevation, however, the identity of...
[会议论文] 作者：Shengjie Feng,Shaorong Ma,Yizheng Wang,
来源：第三届国际神经疾病大会暨2016脑网络与脑疾病高峰论坛 年份：2016
...
TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKⅡα in rat hip
[会议论文] 作者：Zhuohao He,Shengjie Feng,Yizheng Wang,
来源：International Conference for Physiological Sciences 2012(201 年份：2012
Neurotrophin-3 (NT-3) plays numerous important roles in the central nervous system (CNS) and the elevation of intracellular Ca2+ ([Ca2+]i) is critical for these functions of NT-3.However, the mechanis...
[会议论文] 作者：Yichang Jia,Jian Zhou,Yitin Tai,Yizheng Wang,
来源：第八届亚洲大洋洲地区老年学和老年医学大会 年份：2007
...
[会议论文] 作者：Caixia Jia,Hongyu Li,Liu Fan,Yizheng Wang,
来源：The 4th International Ion Channel Conference(第四届国际离子通道会议) 年份：2013
Overactivation of NMDA receptor is a key event in excitotoxicity that induces a sudden intracellular.Ca2+ elevation and finally leads to cell apoptosis and necrosis and inhibition of the Ca2+ overload...
Ca2+ signaling initiated by canonical transient receptor potential channels in dendritic development
[期刊论文] 作者：Shengjie Feng,Zhuohao He,Hongyu Li,Yizheng Wang,
来源：神经科学通报（英文版） 年份：2015
...
[会议论文] 作者：Qing Wang,Qian He,Yifei Chen,Wei Shao,Chao Yuan,Yizheng Wang,
来源：中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 年份：2018
Microglial DICER was phosphorylated at serine 1456 by c-jun N-terminal kinase(JNK)and downregulated in response to 1-methyl-4-phenylpyridinium(MPP+),a causative agent in PD.Inhibition of JNK phosphory...
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ productio
[会议论文] 作者：Junfeng Wang,Rui Lu,Jian Yang,Hongyu Li,Zhuohao He,Naihe Jing,Xiaomin Wang,Yizheng Wang,
来源：The 6th FAONS Congress and 11th Biennial Conference of CNS(第 年份：2015
Accumulation of β-amyloid(Aβ)peptide is critical for the pathogenesis of Alzheimers disease....
[期刊论文] 作者：Zihan Song,Yijie Li,Zijun Zhao,Liqiang Liu,Qianxu Jin,Yizheng Wang,Shiyang Zhang,Zongmao Zhao,
来源：转化神经科学电子杂志（英文） 年份：2021
Objective: gliomas are the most com-mon intracranial tumors. Fibroblast growth factor-12 (FGF12), which belongs to the fibroblast growth factor (FGFs) family, plays an important role in cell mitosis, as well as in other life functions, such......
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ productio
[会议论文] 作者：Junfeng Wang,Rui Lu,Jian Yang,Hongyu Li,Zhuohao He,Qian He,Yuqing Wang,Naihe Jing,Xiaomin Wang,Yizheng Wang,
来源：The 6th FAONS Congress and 11th Biennial Conference of CNS(第 年份：2015
Accumulation of β-amyloid(Aβ)peptide is critical for the pathogenesis of Alzheimers disease.Generation of Aβ involves cleavage of amyloid precursor protein(APP)by γ-secretase,a protease known to cleav...
[会议论文] 作者：Shanshan Li,Jinkui Wang,Yi Wei,Yongjian Liu,Xia Ding,Shaorong Ma,Qing Wang,Bin Dong,Yinghui Xu,Yizheng Wang,
来源：The 6th FAONS Congress and 11th Biennial Conference of CNS(第 年份：2015
...
Probing the therapeutic potential of TRPC6 for Alzheimer’s disease in live neurons from patient-spec
[期刊论文] 作者：Ran Tao,Rui Lu,Junfeng Wang,Shujun Zeng,Ting Zhang,Wenke Guo,Xiaobing Zhang,Qi Cheng,Chunmei Yue,Yizheng Wang,
来源：分子细胞生物学报（英文版） 年份：2020
The induced pluripotent stem cells(iPSCs)offer an unprecedented opportunity to model and study Alzheimer’s disease(AD)under patient-specific genetic background...
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